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Sirtuin Expression in Insulin-Sensitive Tissues of Rats with Impaired Glucose Tolerance is not Affected by Resistance Training or Zinc Supplementation.
Garcia-Díaz, D; Pérez, A; Barham, A; Cano-Cappellacci, M; Vásquez, K; Pérez-Bravo, F; Inostroza, J; Codoceo, J; Orellana, J; Samman, S; Ruz, Manuel.
Afiliação
  • Garcia-Díaz D; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
  • Pérez A; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
  • Barham A; Department de Kinesiology, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Cano-Cappellacci M; Department de Kinesiology, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Vásquez K; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
  • Pérez-Bravo F; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
  • Inostroza J; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
  • Codoceo J; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile.
  • Orellana J; School of Nutrition and Dietetics, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Samman S; School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.
  • Ruz M; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile. mruz@uchile.cl.
Biol Trace Elem Res ; 2024 Oct 01.
Article em En | MEDLINE | ID: mdl-39352663
ABSTRACT
While physical activity and zinc supplementation have shown benefits in diabetes management, little is known about their effect on less severe glucose homeostasis disorders, such as impaired glucose tolerance. On the other hand, sirtuins have an important role in glucose metabolism and insulin sensitivity, but to date, there is no information about the impact of zinc supplementation or physical activity on their regulation in individuals with impaired glucose homeostasis. The aim of this study was to assess the effect of supplemental zinc, muscle-resistance training, and their combination on the expression of selected sirtuins in insulin-sensitive tissues of rats with impaired glucose tolerance. Thirty male Wistar rats with impaired glucose tolerance were fed a high-fat diet for 12 weeks while subjected to zinc supplementation, resistance training, both, or none. Morphometric and metabolic evaluations were performed at the end of the experimental period, and gene expression of sirtuins 1, 2, 4, and 7 was assessed in liver, gastrocnemius muscle, and white adipose tissue. Results showed that zinc supplementation and/or resistance training did not improve metabolic parameters of rats with impaired glucose tolerance, nor did they affect the expression of selected sirtuins in any of the tissues evaluated. However, the expression of some sirtuins was associated with metabolic parameters in a tissue-specific manner. Additional studies are needed to evaluate whether zinc supplementation and/or resistance training can improve metabolic status or modulate sirtuins expression in advanced stages of impaired glucose homeostasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biol Trace Elem Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biol Trace Elem Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos