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Development and validation of a model for early survival prediction following liver transplantation based on donor and recipient characteristics.
Xie, Zhonghao; Lin, Xiaohong; Wang, Yan; Chen, Zhitao; Zeng, Ping; He, Xiaoshun; Ju, Weiqiang; Chen, Maogen.
Afiliação
  • Xie Z; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
  • Lin X; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, P. R. China.
  • Wang Y; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
  • Chen Z; Department of Breast and Thyroid Surgery, Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China.
  • Zeng P; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P. R. China.
  • He X; Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
  • Ju W; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, P. R. China.
  • Chen M; Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Ann Med ; 56(1): 2410404, 2024 Dec.
Article em En | MEDLINE | ID: mdl-39351705
ABSTRACT

BACKGROUND:

Circulating cytokine levels not only correlate with the progression of liver disease but also serve as indicators for the infection status of the body. Growing evidence points to the connection between donor cytokines and graft function following transplantation. This study set out to explore the clinical significance of donor cytokines in predicting liver transplantation prognosis.

METHODS:

Data from 172 deceased donor liver transplantations conducted between 2017 and 2022, with available donor serum cytokine information, were collected. The subjects were randomly divided into estimation (n = 120) and validation (n = 52) groups to establish and validate the model. The newly developed SA10 score was compared against established models EAD, MEAF, L-GrAFT7, and L-GrAFT10.

RESULTS:

Donor IL-10, along with donor age and recipient AST peak value within the first 7 days post-operation, was identified as an independent factor associated with recipient survival and was incorporated into the SA10 score. SA10 exhibited robust predictive capability, particularly for 1-month survival (AUC = 0.90, 95% CI = 0.84-0.96), outperforming EAD (AUC = 0.75, 95% CI = 0.60-0.90, p = 0.04) and L-GrAFT7 (AUC = 0.65, 95% CI = 0.49-0.81, p < 0.01). Comparable performance was observed between SA10, MEAF, and L-GrAFT10.

CONCLUSION:

Donor IL-10 independently influences recipient survival, with the SA10 score demonstrating comparable and even superior predictive ability compared to existing models.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Tecidos / Transplante de Fígado Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Med Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doadores de Tecidos / Transplante de Fígado Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Med Assunto da revista: MEDICINA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido