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Emodin combined with 5-aminolevulinic acid photodynamic therapy inhibits condyloma acuminate angiogenesis by targeting SerRS.
Lu, Hongyan; Peng, Zhangsong; Luo, Yingrui; Zheng, Zhaohui; Li, Changxing; Wang, Qi; Han, Chao; Wang, Youyi; Liang, Liuping; Zeng, Kang; Chen, Yuxiang.
Afiliação
  • Lu H; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Peng Z; Department of Plastic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Luo Y; School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
  • Zheng Z; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Li C; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Wang Q; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Han C; The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, China.
  • Wang Y; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Liang L; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Zeng K; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Chen Y; Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
J Cell Mol Med ; 28(19): e70122, 2024 Oct.
Article em En | MEDLINE | ID: mdl-39351642
ABSTRACT
Human papillomavirus (HPV) infection can cause condyloma acuminatum (CA), which is characterized by a high incidence and a propensity for recurrence after treatment. Angiogenesis plays an important role in the occurrence and development of CA. Seryl-tRNA synthetase (SerRS) is a newly identified, potent anti-angiogenic factor that directly binds to the vascular endothelial growth factor (VEGFA) promoter, thereby suppressing its transcription. Emodin is a natural anthraquinone derivative that can promote SerRS expression. This study aimed to investigate the effects of emodin on CA and explore combined treatment strategies. The HPV-infected cell line SiHa was treated with either DMSO, emodin, ALA-PDT or a combination of emodin and ALA-PDT. We observed the effects on cell proliferation, apoptosis and the SerRS-VEGFA pathway. Our findings demonstrated that emodin targets angiogenesis through the SerRS-VEGFA pathway, resulting in the inhibition of SiHa cell proliferation and promotion of apoptosis (p < 0.001). To verify the therapeutic effect of emodin combined with ALA-PDT on HPV-associated tumours in vivo, we established an animal xenograft model by subcutaneously inoculating mice with SiHa cells (n = 4). The results showed that the combination of emodin and ALA-PDT significantly inhibited the expression of VEGFA to inhibit angiogenesis (p < 0.001), thus showing an inhibitory effect on tumour (p < 0.001). Furthermore, we determined that the mechanism underlying the decrease in VEGFA expression after emodin combined with ALA-PDT in CA may be attributed to the promotion of SerRS expression (p < 0.001). The combination of emodin and ALA-PDT holds promise as a novel therapeutic target for CA by targeting neovascularization in condyloma tissues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Condiloma Acuminado / Emodina / Apoptose / Fator A de Crescimento do Endotélio Vascular / Proliferação de Células / Ácido Aminolevulínico / Neovascularização Patológica Limite: Animals / Female / Humans Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Condiloma Acuminado / Emodina / Apoptose / Fator A de Crescimento do Endotélio Vascular / Proliferação de Células / Ácido Aminolevulínico / Neovascularização Patológica Limite: Animals / Female / Humans Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido