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Early cancer screening surveillance in one medical center of China.
Yang, Ying; Du, Peng; Hou, Xiaolu; Yan, Kun; Dai, Ying; Sun, ZhiYing; Wu, Qi; Li, Shijie; Yan, Yan; Wang, Zhilong; Qi, Liping; Chen, Mailin; Zheng, Hong; Gao, Weijiao; Gao, Min; Xue, Weicheng; Zhang, Xiaodong.
Afiliação
  • Yang Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), The VIP-II Gastrointestinal Cancer Division of Medical Department, Peking University Cancer Hospital & Institute, Beijing, China.
  • Du P; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Urology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Hou X; Western Beijing Cancer Hospital, Beijing, China.
  • Yan K; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Ultrasonography, Peking University Cancer Hospital & Institute, Beijing, China.
  • Dai Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Ultrasonography, Peking University Cancer Hospital & Institute, Beijing, China.
  • Sun Z; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Ultrasonography, Peking University Cancer Hospital & Institute, Beijing, China.
  • Wu Q; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Endoscopy, Peking University Cancer Hospital & Institute, Beijing, China.
  • Li S; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Endoscopy, Peking University Cancer Hospital & Institute, Beijing, China.
  • Yan Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Endoscopy, Peking University Cancer Hospital & Institute, Beijing, China.
  • Wang Z; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Qi L; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Chen M; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Radiology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Zheng H; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Gynecologic Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Gao W; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Gynecologic Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Gao M; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Gynecologic Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Xue W; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.
  • Zhang X; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), The VIP-II Gastrointestinal Cancer Division of Medical Department, Peking University Cancer Hospital & Institute, Beijing, China.
PeerJ ; 12: e18179, 2024.
Article em En | MEDLINE | ID: mdl-39351369
ABSTRACT

Objectives:

Cancer screening aims to detect and treat malignant lesions at an early stage and to prolong patients' lifetime. There is still a lack of effective cancer screening programs in China. We initiated a screening project in 2018 and this study presented the cancer screening status in China.

Methods:

We conducted a cross-sectional study in one cancer-care medical center of China. The screening program included routine blood tests, plasma tumor markers, gastric endoscopy, colonoscopy, ultrasound, and computed tomography (CT) scans. Screening results were presented as sensitivity, specificity and positive predictive values (PPVs).

Results:

Twenty-three (1.46%) out of 1,576 participants were eventually diagnosed with malignant tumors or high-grade intraepithelial neoplasia (HGIN). A family history of malignancy (78.26% in diagnosed cancer and HGIN vs. 46.36% in the others) was the only statistically significant parameter associated with cancer detection (p = 0.002). None of the common tumor markers were associated with the cancers screened. Except for colonoscopy (50.00%) and ultrasound for renal cancer (66.67%), the sensitivities of most screening methods were 100%. The specificities of all the screening means were above 96%. Most PPVs ranged from 30-60%.

Conclusion:

We emphasized risk stratification for early cancer screening, such as a family history of cancer. The survey illustrated that gastric endoscopy, colonoscopy, ultrasound, and lung CT for early cancer screening had high specificity, reasonable sensitivity, and PPV. We anticipated this report would motivate larger-sample studies to estimate the risk-to-benefit ratio of cancer screening and urge the establishment of a native Chinese screening project and even guidelines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Detecção Precoce de Câncer Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: PeerJ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Detecção Precoce de Câncer Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: PeerJ Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos