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SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus.
Lee, Yeon Su; Woo, Jin Seok; Jhun, JooYeon; Choi, Jeong Won; Lee, A Ram; Lee, Kun Hee; Choi, Haeyoun; Park, Sung-Hwan; Cho, Mi-La.
Afiliação
  • Lee YS; Lab of Translational ImmunoMedicine (LaTIM), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Woo JS; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Jhun J; Department of Medical Sciences, Graduate School of The Catholic University of Korea, The Catholic University of Korea, Seoul, South Korea.
  • Choi JW; Lab of Translational ImmunoMedicine (LaTIM), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Lee AR; Lab of Translational ImmunoMedicine (LaTIM), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Lee KH; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Choi H; Department of Medical Sciences, Graduate School of The Catholic University of Korea, The Catholic University of Korea, Seoul, South Korea.
  • Park SH; Lab of Translational ImmunoMedicine (LaTIM), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
  • Cho ML; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Lupus Sci Med ; 11(2)2024 Sep 30.
Article em En | MEDLINE | ID: mdl-39349051
ABSTRACT

OBJECTIVE:

COVID-19 induces the development of autoimmune diseases, including SLE, which are characterised by inflammation, autoantibodies and thrombosis. However, the effects of COVID-19 on SLE remain unclear.

METHODS:

We investigated the effects of COVID-19 on SLE development and progression in three animal models. Plasmids encoding SARS-CoV-2 spike protein and ACE2 receptor were injected into R848-induced BALB/C lupus mice, R848-induced IL-1 receptor antagonist knockout (KO) lupus mice and MRL/lpr mice. Serum levels of albumin and autoantibodies, lymphocyte phenotypes and tissue histology were evaluated.

RESULTS:

In R848-induced BALB/C lupus mice, the SARS-CoV-2 spike protein increased autoantibody and albumin levels compared with vehicle and mock treatments. These mice also exhibited splenomegaly, which was further exacerbated by the spike protein. Flow cytometric analysis revealed elevated T helper 1 cell counts, and histological analysis indicated increased levels of the fibrosis marker protein α-smooth muscle actin. In KO mice, the spike protein induced splenomegaly, severe kidney damage and pronounced lung fibrosis. In the MRL/lpr group, spike protein increased the serum levels of autoantibodies, albumin and the thrombosis marker chemokine (C-X-C motif) ligand 4.

CONCLUSION:

COVID-19 accelerated the development and progression of lupus by inducing autoantibody production, fibrosis and thrombosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Nefrite Lúpica / Camundongos Knockout / Modelos Animais de Doenças / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Lúpus Eritematoso Sistêmico / Camundongos Endogâmicos BALB C Limite: Animals Idioma: En Revista: Lupus Sci Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Nefrite Lúpica / Camundongos Knockout / Modelos Animais de Doenças / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Lúpus Eritematoso Sistêmico / Camundongos Endogâmicos BALB C Limite: Animals Idioma: En Revista: Lupus Sci Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Reino Unido