Your browser doesn't support javascript.
loading
Magnetic resonance-guided laser interstitial thermal therapy versus open surgical corpus callosotomy for pediatric refractory epilepsy: A systematic review and meta-analysis.
Larcipretti, Anna Laura Lima; Gomes, Fernando Cotrim; Udoma-Udofa, Ofonime Chantal; Dagostin, Caroline Serafim; de Oliveira, Jéssica Sales; Nager, Gabriela Borges; Pontes, Julia Pereira Muniz; Bannach, Matheus de Andrade.
Afiliação
  • Larcipretti ALL; School of Medicine, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • Gomes FC; Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Udoma-Udofa OC; Faculty of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
  • Dagostin CS; School of Medicine, University of the Extreme South of Santa Catarina, Criciúma, Brazil.
  • de Oliveira JS; School of Medicine, National University of Rosario, Rosario, Argentina.
  • Nager GB; Faculty of Medicine, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Pontes JPM; Department of Surgical Specialties, Neurosurgery Teaching and Assistance Unit, Pedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Bannach MA; Department of Surgery, Neurology and Neurosurgery Unit, Federal University of Goiás, Goiânia, Brazil. Electronic address: bannachmatheus@gmail.com.
Seizure ; 122: 45-51, 2024 Aug 02.
Article em En | MEDLINE | ID: mdl-39342696
ABSTRACT

PURPOSE:

Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive alternative to traditional open surgery corpus callosotomy (CC). We aim to compare both approaches in terms of time of hospitalization and surgical procedure, complications, and efficacy outcomes.

METHODS:

A systematic search on PubMed, Embase, Web of Science, and Cochrane Library databases was performed for studies directly comparing MRgLITT and open surgery for refractory epilepsy in children.

RESULTS:

A total of 240 patients from five studies were included. There was no statistically significant difference observed between the two groups regarding the favorable Engel outcome. (RR 0.89; 95 % CI 0.70-1.14; p = 0.36; I2=0 %) The mean hospital length of stay (LOS) was significantly shorter in the patients who underwent MRgLITT. (MD -2.84 days; 95 % CI [-3.17]-[-2.51] days; p < 0.00001; I2=90 %) The mean operation duration was significantly longer in the intervention group. (MD 1.38 h; 95 % CI 0.64- 2.12 h; p = 0.00002; I2=55 %). The mean blood loss was significantly lower in patients who underwent MRgLITT. (MD -75.15 ml; 95 % CI [-92.82]-[-57.48] ml; p < 0.00001; I2=0 %)

CONCLUSION:

CC is a valuable option for treating RE, especially in children. The open surgery bears the stigma of an invasive and complicated technique which might justify its underuse. MRgLITT is a great alternative and possibly a way to widen the use of callosotomy in children, however, its cost and availability may be a challenge.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Seizure Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Seizure Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido