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Sex-Specific Behavioral and Molecular Responses to Maternal Lipopolysaccharide-Induced Immune Activation in a Murine Model: Implications for Neurodevelopmental Disorders.
Xu, Jing; Zhao, Rujuan; Yan, Mingyang; Zhou, Meng; Liu, Huanhuan; Wang, Xueying; Lu, Chang; Li, Qiang; Mo, Yan; Zhang, Paihao; Ju, Xingda; Zeng, Xianlu.
Afiliação
  • Xu J; The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Zhao R; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Yan M; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Zhou M; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Liu H; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Wang X; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Lu C; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Li Q; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Mo Y; The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun 130024, China.
  • Zhang P; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Ju X; Jilin Provincial Key Laboratory of Cognitive Neuroscience and Brain Development, School of Psychology, Northeast Normal University, Changchun 130024, China.
  • Zeng X; The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun 130024, China.
Int J Mol Sci ; 25(18)2024 Sep 13.
Article em En | MEDLINE | ID: mdl-39337372
ABSTRACT
Maternal immune activation (MIA) during pregnancy has been increasingly recognized as a critical factor in the development of neurodevelopmental disorders, with potential sex-specific impacts that are not yet fully understood. In this study, we utilized a murine model to explore the behavioral and molecular consequences of MIA induced by lipopolysaccharide (LPS) administration on embryonic day 12.5. Our findings indicate that male offspring exposed to LPS exhibited significant increases in anxiety-like and depression-like behaviors, while female offspring did not show comparable changes. Molecular analyses revealed alterations in pro-inflammatory cytokine levels and synaptic gene expression in male offspring, suggesting that these molecular disruptions may underlie the observed behavioral differences. These results emphasize the importance of considering sex as a biological variable in studies of neurodevelopmental disorders and highlight the need for further molecular investigations to understand the mechanisms driving these sex-specific outcomes. Our study contributes to the growing evidence that prenatal immune challenges play a pivotal role in the etiology of neurodevelopmental disorders and underscores the potential for sex-specific preventative approaches of MIA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Comportamento Animal / Lipopolissacarídeos / Modelos Animais de Doenças / Transtornos do Neurodesenvolvimento Limite: Animals / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Comportamento Animal / Lipopolissacarídeos / Modelos Animais de Doenças / Transtornos do Neurodesenvolvimento Limite: Animals / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Suíça