Your browser doesn't support javascript.
loading
The epidemiological and infectious characteristics of novel types of Coxiella burnetii co-infected with Coxiella-like microorganisms from Xuyi County, Jiangsu province, China.
Ai, Lele; Qi, Yong; Hu, Yue; Zhu, Changqiang; Liu, Kangle; Li, Feng; Ye, Fuqiang; Dai, Han; Wu, Yifan; Kuai, Qiyuan; Nie, Danyue; Shan, Laiyou; Zhang, Yan; Wang, Changjun; Tan, Weilong.
Afiliação
  • Ai L; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Qi Y; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Hu Y; Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Zhu C; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Liu K; Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, China.
  • Li F; Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, China.
  • Ye F; Yancheng Center for Disease Control and Prevention, Yancheng, China.
  • Dai H; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Wu Y; Eastern Theater General Hospital, Nanjing, China.
  • Kuai Q; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Nie D; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Shan L; Nanjing Bioengineer (Gene) Center for Medicines, Nanjing, China.
  • Zhang Y; Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Wang C; Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
  • Tan W; Center for Disease Control and Prevention of PLA, Beijing, China.
BMC Infect Dis ; 24(1): 1041, 2024 Sep 27.
Article em En | MEDLINE | ID: mdl-39333956
ABSTRACT
Coxiella burnetii (C. burnetii) is the causative agent of Q fever, a type of zoonoses withwidespread distribution. In 2019, a case of Q fever was diagnosed by metagenomic next-generation sequencing (mNGS) method in Xuyi County (Jiangsu province, China). The seroprevalence of previous fever patients and the molecular epidemiology of Coxiella in wild hedgehogs and harbouring ticks around the confirmed patient were detected to reveal the genetic characteristics and pathogenicity of the Coxiella strains. Four of the 90 serum samples (4.44%) were positive for specific C. burnetii IgM antibody, suggesting that local humans are at risk of Q fever. The positive rates of C. burnetii in hedgehogs and ticks were 21.9% (7/32) and 70.5% (122/173), respectively. At least 3 strains of Coxiella were found prevalent in the investigated area, including one new genotype of pathogenic C. burnetii (XYHT29) and two non-pathogenic Coxiella-like organisms (XYHT19 and XYHT3). XYHT29 carried by ticks and wild hedgehogs successfully infected mice, imposing a potential threat to local humans. XYHT19, a novel Coxiella-like microorganism, was first discovered in the world to co-infect with C. burnetii in Haemaphysalis flava. The study provided significant epidemic information that could be used for prevention and control strategies against Q fever for local public health departments and medical institutions.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Q / Carrapatos / Coxiella burnetii / Ouriços Limite: Animals / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Q / Carrapatos / Coxiella burnetii / Ouriços Limite: Animals / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: BMC Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido