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Incidence of non-alcoholic fatty liver disease in antiretroviral therapy-naïve people with human immunodeficiency virus who start DTG/ABC/3TC compared to BIC/FTC/TAF at 48-week follow-up.
Cano Díaz, Ana Luz; Triana González, Salma; Salinas Velázquez, Gloria Elizabeth; Mata Marín, José Antonio; Gaytán Martínez, Jesús Enrique; Mauss, Stefan.
Afiliação
  • Cano Díaz AL; Infectious Diseases Department, Hospital de Infectología "La Raza" National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Triana González S; Infectious Diseases Department, Hospital de Infectología "La Raza" National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Salinas Velázquez GE; Imagenology Department, Hospital de Infectología "La Raza" National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Mata Marín JA; Infectious Diseases Department, Hospital de Infectología "La Raza" National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Gaytán Martínez JE; Infectious Diseases Department, Hospital de Infectología "La Raza" National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Mauss S; Center for HIV and Hepatogastroenterology, Düsseldorf, Germany.
Int J STD AIDS ; : 9564624241287886, 2024 Sep 27.
Article em En | MEDLINE | ID: mdl-39331786
ABSTRACT

PURPOSE:

To determine the incidence of non-alcoholic fatty liver disease (NAFLD) by non-invasive methods in people living with HIV (PLWH).

METHODS:

Prospective cohort, in PLWH naïve to antiretroviral therapy, starting bictegravir (BIC) or dolutegravir (DTG) at the Hospital de Infectología "La Raza", in Mexico City, from February 2021 to August 2023. We measured at baseline and 48 weeks triglycerides and glucose index (TyG), fatty liver index (FLI), hepatic steatosis index (HSI) and liver ultrasonography; relative risk (RR) for developing NAFLD was determined.

RESULTS:

At 48 weeks, TyG index in BIC-group 4.54 (IQR 4.36-4.75), in DTG-group 4.66 (IQR 4.49-4.80), p = .080; HSI in BIC-group 30.30 (IQR 28.12-33.70), in DTG-group 30.85 (IQR 28.02-34.50), p = .650; FLI in BIC-group 14.88 (IQR 7.91-31.80), in DTG-group 19.49 (IQR 8.49-32.28), p = .729; NAFLD was detected by US in 6 [10.3% (95%CI 4.8%-20.7%)] in BIC-group and, 7 [10.9% (95%CI 6.4%-20.9%)] in DTG-group, p = .916. Risk factors for NAFLD development were baseline BMI ≥25 kg/m2, baseline HDL-c <40 mg/dL, and FIB-4 >1.3 at 48 weeks.

CONCLUSION:

There is a high incidence of NAFLD in PLWH who start a second generation INSTI at 48 weeks; baseline overweight, low HDL-cholesterol and FIB-4 >1.3 at 48 weeks of treatment were independent risk factors for NAFLD development.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J STD AIDS Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J STD AIDS Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido