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Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao, Xiyu; Fu, Shoupeng; Wen, Jingru; Yan, Aohan; Yang, Shuo; Zhang, Yiming; Liu, Dianfeng; He, Dewei.
Afiliação
  • Gao X; College of Animal Science, Jilin University, Changchun 130062, China.
  • Fu S; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
  • Wen J; College of Veterinary Medicine, Jilin University, Changchun 130062, China.
  • Yan A; College of Animal Science, Jilin University, Changchun 130062, China.
  • Yang S; College of Animal Science, Jilin University, Changchun 130062, China.
  • Zhang Y; College of Animal Science, Jilin University, Changchun 130062, China.
  • Liu D; College of Animal Science, Jilin University, Changchun 130062, China.
  • He D; Chongqing Research Institute, Jilin University, Chongqing 401135, China.
J Agric Food Chem ; 2024 Sep 27.
Article em En | MEDLINE | ID: mdl-39331469
ABSTRACT
Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, the etiology of which remains unclear. Studies have shown that neuroinflammation and oxidative stress (OS) play an important role in neuronal damage in patients with PD. Disturbances in the gut microbiota influence neuroinflammation and OS through the microbiota-gut-brain axis. Ginkgolide C (GC), a traditional Chinese medicine extracted from the leaves of Ginkgo biloba, has been reported to exhibit anti-inflammatory effects and the ability to modulate intestinal microbial composition. However, the potential of GC to positively impact PD by modulating the gut microbiota remains unexplored. This study aimed to explore the effects of GC on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD in mice and elucidate its underlying mechanisms. Our findings elucidated that GC treatment significantly ameliorates behavioral deficits as well as pathological damage via restoring gut microbial homeostasis to downgrade OS and neuroinflammation in MPTP-induced PD mice. Mechanistically, GC treatment exerts antioxidant effects via activating the AKT/Nrf2/HO-1 pathway in MPP+-exposed SN4741 neuronal cells and significantly downregulates the expression of inflammatory mediators via regulating NF-κB and MAPK signaling in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Overall, our study demonstrates that GC administration alleviates MPTP-induced neurodegeneration via rebuilding gut microbial homeostasis to inhibit OS and neuroinflammation in mice, indicating that GC might serve as a promising candidate medicine for PD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Agric Food Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Agric Food Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos