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A pH-Responsive Hydrogel for the Oral Delivery of Ursolic Acid: A Pentacyclic Triterpenoid Phytochemical.
Gutierrez, Carlos D; Aranzábal, Rosana L; Lechuga, Ana M; Serrano, Carlos A; Meza, Flor; Elvira, Carlos; Gallardo, Alberto; Ludeña, Michael A.
Afiliação
  • Gutierrez CD; Department of Chemistry, Faculty of Chemical, Physical and Mathematical Sciences, National University of San Antonio Abad del Cusco (UNSAAC), Av. De la Cultura 733, Cusco 921, Peru.
  • Aranzábal RL; Department of Chemistry, Faculty of Chemical, Physical and Mathematical Sciences, National University of San Antonio Abad del Cusco (UNSAAC), Av. De la Cultura 733, Cusco 921, Peru.
  • Lechuga AM; Department of Chemistry, Faculty of Chemical, Physical and Mathematical Sciences, National University of San Antonio Abad del Cusco (UNSAAC), Av. De la Cultura 733, Cusco 921, Peru.
  • Serrano CA; Department of Chemistry, Faculty of Chemical, Physical and Mathematical Sciences, National University of San Antonio Abad del Cusco (UNSAAC), Av. De la Cultura 733, Cusco 921, Peru.
  • Meza F; Technology of Materials for Environmental Remediation Group (TecMARA), Faculty of Sciences, National University of Engineering, Av. Tupac Amaru 210, Rimac 15333, Peru.
  • Elvira C; Institute of Polymer Science and Technology (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
  • Gallardo A; Institute of Polymer Science and Technology (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
  • Ludeña MA; Department of Chemistry, Faculty of Chemical, Physical and Mathematical Sciences, National University of San Antonio Abad del Cusco (UNSAAC), Av. De la Cultura 733, Cusco 921, Peru.
Gels ; 10(9)2024 Sep 22.
Article em En | MEDLINE | ID: mdl-39330204
ABSTRACT
In this study, poly(HEMA-PEGxMEM-IA) hydrogels were prepared by radical copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGxMEM), 2-hydroxyethyl methacrylate (HEMA), and itaconic acid (IA). The reaction was carried out in ethanolic solution using N,N'-methylenebisacrylamide (MBA) as a crosslinking agent and 1-hydroxycyclohexyl phenyl ketone (HCPK) as a photo-initiator. The poly(HEMA-PEGxMEM-IA) hydrogels (HGx) were evaluated as a delivery system for ursolic acid (UA), a phytochemical extracted from the plant Clinopodium revolutum, "flor de arena". The hydrogels were characterized by Fourier-transform infrared spectroscopy (FTIR-ATR), Raman spectroscopy, X-Ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The swelling behavior was studied in buffer solutions from pH 2 to 10, specifically at pH 2.2 (gastric environment) and 7.4 (intestinal environment). It was found that the hydrogels studied showed sensitivity to pH. At pH 2.2, the degree of swelling for HG5 and HG9 hydrogels was 0.45 and 0.93 (g water/g hydrogel), respectively. At pH 7.4, the degree of swelling for HG5 and HG9 hydrogels was 1.97 and 2.64 (g water/g hydrogel), respectively. The SEM images show the variation in pore size as a function of pH, and the UA crystals in the pores of the hydrogels can also be observed. The in vitro UA release data best fit the Korsmeyer-Peppas kinetic model and the diffusion exponent indicates that the release mechanism is governed by Fickian diffusion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Gels Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Peru País de publicação: Suíça
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Gels Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Peru País de publicação: Suíça