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Circulating tumor DNA in diffuse large B-cell lymphoma: analysis of response assessment, correlation with PET/CT and clone evolution.
Duffles, Guilherme; Maués, Jersey Heitor da Silva; Lupinacci, Fernanda; Pereira, Luciana Guilhermino; Ferreira, Elisa Napolitano; Freitas, Leandro; Niemann, Fernanda; Takahashi, Maria Emilia Seren; Ramos, Celso Darío; Chauffaille, Maria de Lourdes L Ferrari; Lorand-Metze, Irene.
Afiliação
  • Duffles G; University of Campinas, Hematology and Hemotherapy Centre, Hematology, Unicamp, Campinas 13083-878, SP, Brazil; Rede Dor Sao Luiz, Sao Paulo 01401-002, SP, Brazil. Electronic address: gbda@unicamp.br.
  • Maués JHDS; University of Campinas, Hematology and Hemotherapy Centre, Hematology, Unicamp, Campinas 13083-878, SP, Brazil.
  • Lupinacci F; Fleury Medicina e Saúde, Grupo Fleury, São Paulo 04580-060, SP, Brazil.
  • Pereira LG; Fleury Medicina e Saúde, Grupo Fleury, São Paulo 04580-060, SP, Brazil.
  • Ferreira EN; Fleury Medicina e Saúde, Grupo Fleury, São Paulo 04580-060, SP, Brazil.
  • Freitas L; Department of Pathology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, 13083-888, SP, Brazil.
  • Niemann F; University of Campinas, Hematology and Hemotherapy Centre, Hematology, Unicamp, Campinas 13083-878, SP, Brazil.
  • Takahashi MES; Gleb Wataghin Institute of Physics, University of Campinas (UNICAMP), Campinas 13083-859, SP, Brazil.
  • Ramos CD; Division of Nuclear Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-888, SP, Brazil.
  • Chauffaille MLLF; Fleury Medicina e Saúde, Grupo Fleury, São Paulo 04580-060, SP, Brazil.
  • Lorand-Metze I; University of Campinas, Hematology and Hemotherapy Centre, Hematology, Unicamp, Campinas 13083-878, SP, Brazil.
Hematol Transfus Cell Ther ; 2024 Sep 20.
Article em En | MEDLINE | ID: mdl-39317576
ABSTRACT

INTRODUCTION:

Circulating tumor DNA (ctDNA) can be obtained from cell-free DNA (cfDNA) andis a new technique for genotyping, response assessment and prognosis in lymphoma.

METHODS:

Eighteen patients with samples at diagnosis (ctDNA1), after treatment (ctDNA2) and extracted from diagnostic tissue (FFPE) were evaluated.

RESULTS:

In all patients, at least one mutation in cfDNA was detected at diagnosis. CREBBP was the most frequent mutated gene (67 %). In 12 of the 15 patients with complete remission, the mutation attributed to the disease found at diagnosis cleared with treatment. A reduction in the ctDNA was observed after treatment in 14 patients, 12 of whom achieved complete remission. Correlations were found between the ctDNA at diagnosis and total metabolic tumor volume (r = 0.51; p-value = 0.014) and total lesion glycolysis 2.5 (r = 0.47; p-value = 0.024) by PET at diagnosis and between ctDNA at diagnosis and radiomic features of the lesions with the largest standardized uptake value. There was a strong inverse correlation between ΔctDNA1 and ΔSUVmax by PET/CT (r = -0.8788; p-value = 0.002).

CONCLUSION:

Analysis of ctDNA and PET/CT in large B-cell lymphoma are complementary data for evaluating tumor burden and tumor clearance after treatment. Analysis of radiomic data might help to identify tumor characteristics and their changes after treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Hematol Transfus Cell Ther Ano de publicação: 2024 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Hematol Transfus Cell Ther Ano de publicação: 2024 Tipo de documento: Article País de publicação: Brasil