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Malignant transformation of oral leukoplakia: Systematic review and comprehensive meta-analysis.
Pimenta-Barros, Liliana Aparecida; Ramos-García, Pablo; González-Moles, Miguel Ángel; Aguirre-Urizar, José Manuel; Warnakulasuriya, Saman.
Afiliação
  • Pimenta-Barros LA; Dental Sciences Graduate Program, Federal University of Espirito Santo, Vitoria, Brazil.
  • Ramos-García P; Instituto de Investigación Biosanitaria, School of Dentistry, University of Granada, Granada, Spain.
  • González-Moles MÁ; Instituto de Investigación Biosanitaria, School of Dentistry, University of Granada, Granada, Spain.
  • Aguirre-Urizar JM; Oral and Maxillofacial Medicine & Pathology Unit, Department of Stomatology, Faculty of Medicine and Nursery, University of the Basque Country/EHU, Leioa, Spain.
  • Warnakulasuriya S; Faculty of Dental, Oral & Craniofacial Sciences, WHO Collaborating Centre for Oral Cancer, King's College London, London, UK.
Oral Dis ; 2024 Sep 24.
Article em En | MEDLINE | ID: mdl-39314164
ABSTRACT

OBJECTIVES:

To update the current evidence on the malignant transformation of oral leukoplakia (OL), including all studies published worldwide on the subject, selected with the maximum rigor regarding eligibility. MATERIALS AND

METHODS:

MEDLINE, Embase, Web of Science and Scopus were searched for studies published before June-2024, with no lower date limit. The risk of bias was analyzed using the Joanna Briggs Institute tool for meta-analyses of proportions. We carried out meta-analyses, explored heterogeneity across subgroups and identified risk factors with potential prognostic value.

RESULTS:

Fifty-five studies (41,231 with OL) were included. The pooled malignant transformation proportion for OL was 6.64% (95% CI = 5.21-8.21). The malignant transformation did not significantly vary by time periods (p = 0.75), 5.35% prior to 1978, 7.06% from 1979 to 2007 and 6.97% during more recent times. The risk factors that significantly had a higher impact on malignant transformation were the non-homogeneous leukoplakias (RR = 4.23, 95% CI = 3.31-5.39, p < 0.001), the larger size (RR = 2.08, 1.45-2.96, p < 0.001), leukoplakia located on the lateral border of tongue (malignant transformation = 12.71%; RR = 2.09, 95% CI = 1.48-2.95, p < 0.001), smoking (RR = 1.64, 95% CI = 1.25-2.15, p < 0.001), and the presence of epithelial dysplasia (RR = 2.75, 95% CI = 2.26-3.35, p < 0.001).

CONCLUSIONS:

OL presents a considerable malignant transformation probability that is especially increased in large non-homogeneous lesions in smokers, located on the lateral border of the tongue, with epithelial dysplasia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Oral Dis Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Oral Dis Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca