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Anti-Müllerian hormone as a predictor of the number of oocytes obtained during in vitro fertilization treatments.
Reis, Ana Braga; Leal, Carla; Barreiro, Márcia; Tomé, António; Vale-Fernandes, Emídio.
Afiliação
  • Reis AB; Unidade de Saúde Familiar Porta do Sol, Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal.
  • Leal C; ICBAS - School of Medicine and Biomedical Sciences, UMIB - Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.
  • Barreiro M; Centro de Procriação Medicamente Assistida/Banco Público de Gâmetas, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Unidade Local de Saúde de Santo António (ULSSA), Porto, Portugal.
  • Tomé A; Departamento da Mulher e da Medicina Reprodutiva, Centro Materno-Infantil do Norte Dr. Albino Aroso (CMIN), Unidade Local de Saúde de Santo António (ULSSA), Porto, Portugal.
  • Vale-Fernandes E; ITR - Laboratory for Integrative and Translational Research in Population Health, University of Porto, Porto, Portugal.
JBRA Assist Reprod ; 2024 Sep 23.
Article em En | MEDLINE | ID: mdl-39311652
ABSTRACT

OBJECTIVE:

To evaluate the correlation between serum anti-Müllerian hormone (AMH) and the number of oocytes retrieved after controlled ovarian stimulation for in vitro fertilization treatments and determine cut-off values predictive of poor and high response to stimulation.

METHODS:

It was performed a retrospective observational study that included 1003 cycles of controlled ovarian stimulation carried between February 2017 and December 2023 at a Medically Assisted Procreation Centre. The exclusion criteria were the following serum AMH levels obtained more than 6 months prior to the start of the ovarian stimulation, the presence of a single ovary, non-Caucasian ethnicity, a controlled ovarian stimulation cycle performed for the purpose of oocyte donation or fertility preservation, a documented diagnosis of endometriosis, a documented history of ovarian surgery and the absence of essential data for the study in the medical records (absence of the number of oocytes obtained or the AMH value). Poor response to stimulation was defined as ≤ 3 oocytes retrieved, and high response was defined as > 15 oocytes. The correlation between variables was calculated using Spearman's correlation test and cut-off values were determined using ROC (Receiver Operating Characteristic) curves.

RESULTS:

AMH exhibited a significantly positive correlation with the number of oocytes retrieved (Spearman's correlation coefficient = 0.60, p<0.01). The predictive cut-off for poor ovarian response was 0.72 ng/mL (specificity of 95.13%, sensitivity of 43.23%), and the predictive cut-off for high ovarian response was 4.77 ng/mL (specificity of 89.86%, sensitivity of 38.22%).

CONCLUSIONS:

Serum AMH proved to be a good predictor of the ovarian response to controlled ovarian stimulation for in vitro fertilization treatments, which makes it useful in supporting clinical decision-making. However, it should not be used as an absolute discriminator of poor or high ovarian response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Portugal País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Portugal País de publicação: Brasil