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Detection properties of indium-111 and IRDye800CW for intraoperative molecular imaging use across tissue phantom models.
Sever, ReidAnn E; Rosenblum, Lauren T; Stanley, Kayla C; Cortez, Angel G; Menendez, Dominic M; Chagantipati, Bhuvitha; Nedrow, Jessie R; Edwards, W Barry; Malek, Marcus M; Kohanbash, Gary.
Afiliação
  • Sever RE; University of Pittsburgh, Department of Neurological Surgery, Pittsburgh, Pennsylvania, United States.
  • Rosenblum LT; University of Pittsburgh, Department of Surgery, Pittsburgh, Pennsylvania, United States.
  • Stanley KC; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
  • Cortez AG; University of Pittsburgh Medical Center, In Vivo Imaging Facility Core, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States.
  • Menendez DM; University of Missouri, Department of Biochemistry, Columbia, Missouri, United States.
  • Chagantipati B; University of Pittsburgh, Department of Neurological Surgery, Pittsburgh, Pennsylvania, United States.
  • Nedrow JR; University of Pittsburgh Medical Center, In Vivo Imaging Facility Core, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States.
  • Edwards WB; University of Missouri, Department of Biochemistry, Columbia, Missouri, United States.
  • Malek MM; University of Pittsburgh, Department of Surgery, Pittsburgh, Pennsylvania, United States.
  • Kohanbash G; University of Pittsburgh School of Medicine, Division of Pediatric General and Thoracic Surgery, Department of Surgery, Pittsburgh, Pennsylvania, United States.
J Biomed Opt ; 30(Suppl 1): S13705, 2025 Jan.
Article em En | MEDLINE | ID: mdl-39310036
ABSTRACT

Significance:

Intraoperative molecular imaging (IMI) enables the detection and visualization of cancer tissue using targeted radioactive or fluorescent tracers. While IMI research has rapidly expanded, including the recent Food and Drug Administration approval of a targeted fluorophore, the limits of detection have not been well-defined.

Aim:

The ability of widely available handheld intraoperative tools (Neoprobe and SPY-PHI) to measure gamma decay and fluorescence intensity from IMI tracers was assessed while varying characteristics of both the signal source and the intervening tissue or gelatin phantoms.

Approach:

Gamma decay signal and fluorescence from tracer-bearing tumors (TBTs) and modifiable tumor-like inclusions (TLIs) were measured through increasing thicknesses of porcine tissue and gelatin in custom 3D-printed molds. TBTs buried beneath porcine tissue were used to simulate IMI-guided tumor resection.

Results:

Gamma decay from TBTs and TLIs was detected through significantly thicker tissue and gelatin than fluorescence, with at least 5% of the maximum signal observed through up to 5 and 0.5 cm, respectively, depending on the overlying tissue type or gelatin.

Conclusions:

We developed novel systems that can be fine-tuned to simulate variable tumor characteristics and tissue environments. These were used to evaluate the detection of fluorescent and gamma signals from IMI tracers and simulate IMI surgery.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos de Índio / Imagens de Fantasmas / Imagem Molecular / Indóis Limite: Animals Idioma: En Revista: J Biomed Opt Assunto da revista: ENGENHARIA BIOMEDICA / OFTALMOLOGIA Ano de publicação: 2025 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radioisótopos de Índio / Imagens de Fantasmas / Imagem Molecular / Indóis Limite: Animals Idioma: En Revista: J Biomed Opt Assunto da revista: ENGENHARIA BIOMEDICA / OFTALMOLOGIA Ano de publicação: 2025 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos