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Serum Procalcitonin, Hematology Parameters, and Cell Morphology in Multiple Clinical Conditions and Sepsis.
Feng, Pingfeng; He, Yongjian; Guan, Ping; Duan, Chaohui; Huang, Junjie; Chai, Zhixin; Wang, Jingjing; Zheng, Huifei; Luo, Junxu; Shi, Yuhuan; Li, Xin; Huang, Huayi.
Afiliação
  • Feng P; Department of Laboratory Medicine, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China.
  • He Y; Department of Laboratory Medicine, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China.
  • Guan P; Department of Laboratory Medicine, Guangzhou Thoracic Hospital, Guangzhou, Guangdong, China.
  • Duan C; Department of Laboratory Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
  • Huang J; Department of Laboratory Medicine, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China.
  • Chai Z; Department of Laboratory Medicine, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China.
  • Wang J; Division of the In Vitro Diagnostics, Mindray Corporation, Shenzhen, Guangdong, China.
  • Zheng H; Division of the In Vitro Diagnostics, Mindray North America, Mahwah, New Jersey, USA.
  • Luo J; Division of the In Vitro Diagnostics, Mindray Corporation, Shenzhen, Guangdong, China.
  • Shi Y; Division of the In Vitro Diagnostics, Mindray North America, Mahwah, New Jersey, USA.
  • Li X; Division of the In Vitro Diagnostics, Mindray Corporation, Shenzhen, Guangdong, China.
  • Huang H; Division of the In Vitro Diagnostics, Mindray North America, Mahwah, New Jersey, USA.
J Clin Lab Anal ; : e25100, 2024 Sep 21.
Article em En | MEDLINE | ID: mdl-39305165
ABSTRACT

BACKGROUND:

The clinical value of procalcitonin (PCT) in infection diagnosis and antibiotic stewardship is still unclear. This study aimed to investigate the association between serum PCT and different clinical conditions as well as other infectious/inflammatory parameters in different septic patients in order to elucidate the value of PCT detection in infection management.

METHODS:

Chemiluminescence immunoassay was used for serum PCT analysis. Hematology analysis was used for complete blood cell count. Digital automated cell morphology analysis was used for blood cell morphology examination. Blood, urine, and stool cultures were performed according to routine clinical laboratory standard operating procedures. C-reactive protein (CRP) was analyzed by immunoturbidimetry. Erythrocyte sedimentation rate test was performed using natural sedimentation methods.

RESULTS:

Outpatients, ICU patients, and patients under 2 years of age with respiratory infections had higher serum PCT levels. Septic patients had the highest-serum PCT levels and other infection indexes. PCT levels in the blood, urine, and stool culture-positive patients were significantly higher than in culture-negative patients. The neutrophil granulation and reactive lymphocytes were observed together with the PCT-level increments in different septic patients, and these alterations were lessened after treatment. There was no significant change in monocyte morphology between pre- and posttreatment septic patients.

CONCLUSIONS:

Serum PCT is associated with neutrophil cytotoxicity and lymphocyte morphology changes in sepsis; thus, the combination of neutrophil and lymphocyte digital cell morphology evaluations with PCT detection may be a useful examination for guiding the clinical management of sepsis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Lab Anal Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Lab Anal Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos