The RNA-binding proteins regulate innate antiviral immune signaling by modulating pattern recognition receptors.

Li, Jianguo; Yu, Jingge; Shen, Ao; Lai, Suwen; Liu, Zhiping; He, Tian-Sheng

Li, Jianguo; Yu, Jingge; Shen, Ao; Lai, Suwen; Liu, Zhiping; He, Tian-Sheng.

Afiliação

Li J; School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, 341000, China.
Yu J; Center for Immunology, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, China.
Shen A; Graduate School, Gannan Medical University, Ganzhou, Jiangxi, China.
Lai S; School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, 341000, China.
Liu Z; Department of Blood Transfusion, Jingmen Central Hospital, Jingmen, China.
He TS; School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, 341000, China.

Virol J ; 21(1): 225, 2024 Sep 20.

Article em En | MEDLINE | ID: mdl-39304943

ABSTRACT

ABSTRACT

Viral infections pose significant threats to human health, leading to a diverse spectrum of infectious diseases. The innate immune system serves as the primary barrier against viruses and bacteria in the early stages of infection. A rapid and forceful antiviral innate immune response is triggered by distinguishing between self-nucleic acids and viral nucleic acids. RNA-binding proteins (RBPs) are a diverse group of proteins which contain specific structural motifs or domains for binding RNA molecules. In the last decade, numerous of studies have outlined that RBPs influence viral replication via diverse mechanisms, directly recognizing viral nucleic acids and modulating the activity of pattern recognition receptors (PRRs). In this review, we summarize the functions of RBPs in regulation of host-virus interplay by controlling the activation of PRRs, such as RIG-I, MDA5, cGAS and TLR3. RBPs are instrumental in facilitating the identification of viral RNA or DNA, as well as viral structural proteins within the cellular cytoplasm and nucleus, functioning as co-receptor elements. On the other hand, RBPs are capable of orchestrating the activation of PRRs and facilitating the transmission of antiviral signals to downstream adaptor proteins by post-translational modifications or aggregation. Gaining a deeper comprehension of the interaction between the host and viruses is crucial for the development of novel therapeutics targeting viral infections.

Assuntos

Imunidade Inata; Proteínas de Ligação a RNA; Receptores de Reconhecimento de Padrão; Transdução de Sinais; Receptores de Reconhecimento de Padrão/metabolismo; Receptores de Reconhecimento de Padrão/imunologia; Humanos; Proteínas de Ligação a RNA/metabolismo; Proteínas de Ligação a RNA/imunologia; Proteínas de Ligação a RNA/genética; Animais; Viroses/imunologia; Viroses/virologia; Interações Hospedeiro-Patógeno/imunologia; RNA Viral/metabolismo; RNA Viral/imunologia; RNA Viral/genética; Vírus/imunologia; Replicação Viral

Palavras-chave

Host-virus interplay; Innate immunity; Pattern recognition receptors; RNA-binding proteins

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas de Ligação a RNA / Receptores de Reconhecimento de Padrão / Imunidade Inata Limite: Animals / Humans Idioma: En Revista: Virol J Assunto da revista: VIROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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