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Recent Advances in Discovery, Structure, Bioactivity, and Biosynthesis of trans-AT Polyketides.
Di, Xue; Li, Peng; Xiahou, Yinuo; Wei, Huamao; Zhi, Shuai; Liu, Liwei.
Afiliação
  • Di X; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China.
  • Li P; College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang 315832, China.
  • Xiahou Y; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China.
  • Wei H; College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang 315832, China.
  • Zhi S; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China.
  • Liu L; College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang 315832, China.
J Agric Food Chem ; 72(39): 21318-21343, 2024 Oct 02.
Article em En | MEDLINE | ID: mdl-39302874
ABSTRACT
Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are among the most complex enzymes, which are responsible for generating a wide range of natural products, identified as trans-AT polyketides. These polyketides have received significant attention in drug development due to their structural diversity and potent bioactivities. With approximately 300 synthesized molecules discovered so far, trans-AT PKSs are found widespread in bacteria. Their biosynthesis pathways exhibit considerable genetic diversity, leading to the emergence of numerous enzymes with novel mechanisms, serving as a valuable resource for genetic engineering aimed at modifying small molecules' structures and creating new engineered enzymes. Despite the systematic discussions on trans-AT polyketides and their biosynthesis in earlier studies, the continuous advancements in tools, methods, compound identification, and biosynthetic pathways require a fresh update on accumulated knowledge. This review seeks to provide a comprehensive discussion for the 27 types of trans-AT polyketides discovered within the last seven years, detailing their sources, structures, biological activities, and biosynthetic pathways. By reviewing this new knowledge, a more profound understanding of the trans-AT polyketide family can be achieved.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Policetídeo Sintases / Vias Biossintéticas / Policetídeos Limite: Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Policetídeo Sintases / Vias Biossintéticas / Policetídeos Limite: Humans Idioma: En Revista: J Agric Food Chem Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos