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Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review).
Qu, Peng; Li, Lanfang; Jin, Qi; Liu, Donghai; Qiao, Yuan; Zhang, Yijia; Sun, Qiuyue; Ran, Shuman; Li, Zecheng; Liu, Tongtong; Peng, Liang.
Afiliação
  • Qu P; Institute of Clinical Medical Sciences, China­Japan Friendship Hospital, Beijing 100029, P.R. China.
  • Li L; Institute of Clinical Medical Sciences, China­Japan Friendship Hospital, Beijing 100029, P.R. China.
  • Jin Q; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100029, P.R. China.
  • Liu D; China­Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100029, P.R. China.
  • Qiao Y; China­Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100029, P.R. China.
  • Zhang Y; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, P.R. China.
  • Sun Q; Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, P.R. China.
  • Ran S; Institute of Clinical Medical Sciences, China­Japan Friendship Hospital, Beijing 100029, P.R. China.
  • Li Z; Institute of Clinical Medical Sciences, China­Japan Friendship Hospital, Beijing 100029, P.R. China.
  • Liu T; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100029, P.R. China.
  • Peng L; Institute of Clinical Medical Sciences, China­Japan Friendship Hospital, Beijing 100029, P.R. China.
Int J Mol Med ; 54(5)2024 Nov.
Article em En | MEDLINE | ID: mdl-39301658
ABSTRACT
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end­stage renal disease, and is characterized by persistent proteinuria and decreased glomerular filtration rate. Despite extensive efforts, the increasing incidence highlights the urgent need for more effective treatments. Histone methylation is a crucial epigenetic modification, and its alteration can destabilize chromatin structure, thereby regulating the transcriptional activity of specific genes. Histone methylation serves a substantial role in the onset and progression of various diseases. In patients with DKD, changes in histone methylation are pivotal in mediating the interactions between genetic and environmental factors. Targeting these modifications shows promise in ameliorating renal histological manifestations, tissue fibrosis and proteinuria, and represents a novel therapeutic frontier with the potential to halt DKD progression. The present review focuses on the alterations in histone methylation during the development of DKD, systematically summarizes its impact on various renal parenchymal cells and underscores the potential of targeted histone methylation modifications in improving DKD outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Epigênese Genética / Nefropatias Diabéticas Limite: Animals / Humans Idioma: En Revista: Int J Mol Med Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Grécia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Epigênese Genética / Nefropatias Diabéticas Limite: Animals / Humans Idioma: En Revista: Int J Mol Med Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Grécia