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Vector competence of Culex quinquefasciatus for Tembusu virus and viral factors for virus transmission by mosquitoes.
Tang, Yibin; He, Yu; Wang, Xiaoli; Wu, Zhen; Du, Senyan; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Zhao, Xinxin; Yang, Qiao; Wu, Ying; Zhang, Shaqiu; Huang, Juan; Ou, Xumin; Sun, Di; Cheng, Anchun; Chen, Shun.
Afiliação
  • Tang Y; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • He Y; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Wang X; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Wu Z; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Du S; Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Chengdu, 611130, Sichuan, China.
  • Wang M; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Jia R; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Zhu D; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Liu M; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Zhao X; Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Chengdu, 611130, Sichuan, China.
  • Yang Q; Research Center for Swine Diseases, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Wu Y; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Zhang S; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Huang J; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Ou X; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Sun D; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Cheng A; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
  • Chen S; Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Vet Res ; 55(1): 109, 2024 Sep 18.
Article em En | MEDLINE | ID: mdl-39294772
ABSTRACT
The ongoing epidemic of flaviviruses worldwide has underscored the importance of studying flavivirus vector competence, considering their close association with mosquito vectors. Tembusu virus is an avian-related mosquito-borne flavivirus that has been an epidemic in China and Southeast Asia since 2010. However, the reason for the outbreak of Tembusu virus in 2010 remains unclear, and it is unknown whether changes in vector transmission played an essential role in this process. To address these questions, we conducted a study using Culex quinquefasciatus as a model for Tembusu virus infection, employing both oral infection and microinjection methods. Our findings confirmed that both vertical and venereal transmission collectively contribute to the cycle of Tembusu virus within the mosquito population, with persistent infections observed. Importantly, our data revealed that the prototypical Tembusu virus MM_1775 strain exhibited significantly greater infectivity and transmission rates in mosquitoes than did the duck Tembusu virus (CQW1 strain). Furthermore, we revealed that the viral E protein and 3' untranslated region are key elements responsible for these differences. In conclusion, our study sheds light on mosquito transmission of Tembusu virus and provides valuable insights into the factors influencing its infectivity and transmission rates. These findings contribute to a better understanding of Tembusu virus epidemiology and can potentially aid in the development of strategies to control its spread.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Flavivirus / Culex / Flavivirus / Mosquitos Vetores Limite: Animals Idioma: En Revista: Vet Res Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Flavivirus / Culex / Flavivirus / Mosquitos Vetores Limite: Animals Idioma: En Revista: Vet Res Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido