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Senescent CD4+ T-Cell Phenotypes and Inflammatory Milieu in the Coronary and Systemic Circulation in ST-Elevation Myocardial Infarction: An Exploratory Study.
Bocanegra-Zamora, Fernanda; Espinosa-Bautista, Fernanda; Jiménez-Rodríguez, Gian M; Masso, Felipe; Paez, Araceli; Gonzalez-Pacheco, Hector; Patlán, Mariana; Eid-Lidt, Guering; Amezcua-Guerra, Luis M.
Afiliação
  • Bocanegra-Zamora F; Immunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Espinosa-Bautista F; Immunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Jiménez-Rodríguez GM; Master in Chemobiological Sciences, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
  • Masso F; Interventional Cardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Paez A; UNAM/INC Translational Research Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Gonzalez-Pacheco H; UNAM/INC Translational Research Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Patlán M; Coronary Care Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Eid-Lidt G; Basic Research Sub directorate, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Amezcua-Guerra LM; Interventional Cardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
J Vasc Res ; 61(5): 260-266, 2024.
Article em En | MEDLINE | ID: mdl-39293415
ABSTRACT

INTRODUCTION:

In ST-elevation myocardial infarction (STEMI), inflammation is pivotal, with early senescent CD4+CD28null cells implicated in its pathogenesis. However, the functional phenotype of these cells within the coronary circulation remains unclear.

METHODS:

We examined CD4+ cell subpopulations in blood samples from the coronary sinus and vena cava of 24 STEMI patients and the cephalic vein of seven healthy controls.

RESULTS:

Our findings revealed reduced CD4+ cell counts in STEMI patients compared to controls (1,998, 1,275-3,268 vs. 4,278, 3,595-4,449), alongside an increased proportion of CD4+ cells lacking CD28 expression (20.1 vs. 6.1%). These CD4+CD28null cells in STEMI predominantly exhibited a Th1 phenotype (47.8% vs. 6.6%). Intriguingly, no significant differences were detected in CD4+CD28null cells between coronary sinus and vena cava, and cytokine levels in these compartments remained similar.

CONCLUSION:

CD4+CD28null cells are increased in STEMI, mainly polarized toward a Th1 phenotype, and distributed equally between the different vascular beds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Linfócitos T CD4-Positivos / Citocinas / Antígenos CD28 / Células Th1 / Circulação Coronária / Infarto do Miocárdio com Supradesnível do Segmento ST Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Vasc Res Assunto da revista: ANGIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenótipo / Linfócitos T CD4-Positivos / Citocinas / Antígenos CD28 / Células Th1 / Circulação Coronária / Infarto do Miocárdio com Supradesnível do Segmento ST Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Vasc Res Assunto da revista: ANGIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça