Coenzymes in a pre-enzymatic metabolism.

Dherbassy, Quentin; Mayer, Robert J; Moran, Joseph

Dherbassy, Quentin; Mayer, Robert J; Moran, Joseph.

Afiliação

Dherbassy Q; Institut de Science et d'Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg - 8 Allée Gaspard Monge, 67000 Strasbourg, France.
Mayer RJ; Technische Universität München, School of Natural Sciences, Lichtenbergstr. 4, 85748 Garching, Germany.
Moran J; Institut de Science et d'Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg - 8 Allée Gaspard Monge, 67000 Strasbourg, France.

Sci Adv ; 10(38): eadr5357, 2024 Sep 20.

Article em En | MEDLINE | ID: mdl-39292780

ABSTRACT

ABSTRACT

Experiments now support theoretical suggestions that coenzymes mediated key metabolic reactions before the emergence of enzymes. Three coenzymes believed essential to the core metabolism of the last universal common ancestor to extant life (pyridoxal phosphate, adenosine diphosphate, and nicotinamide adenine dinucleotide) were recently found to be active in their corresponding metabolic reactions in the absence of enzymes. These findings suggest an earlier contribution of coenzymes to abiogenesis, ultimately yielding insights into the prebiotic origins of metabolism.

Assuntos

Coenzimas; Coenzimas/metabolismo; Enzimas/metabolismo; NAD/metabolismo; Origem da Vida; Difosfato de Adenosina/metabolismo; Fosfato de Piridoxal/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coenzimas Idioma: En Revista: Sci Adv Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos

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