Effects of mobility, immunity and vaccination on SARS-CoV-2 transmission in the Dominican Republic: a modelling study.
Lancet Reg Health Am
; 37: 100860, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39281423
ABSTRACT
Background:
COVID-19 dynamics are driven by a complex interplay of factors including population behaviour, new variants, vaccination and immunity from prior infections. We quantify drivers of SARS-CoV-2 transmission in the Dominican Republic, an upper-middle income country of 10.8 million people. We then assess the impact of the vaccination campaign implemented in February 2021, primarily using CoronaVac, in saving lives and averting hospitalisations.Methods:
We fit an age-structured, multi-variant transmission dynamic model to reported deaths, hospital bed occupancy, and seroprevalence data until December 2021, and simulate epidemic trajectories under different counterfactual scenarios.Findings:
We estimate that vaccination averted 7210 hospital admissions (95% credible interval, CrI 6830-7600), 2180 intensive care unit admissions (95% CrI 2080-2280) and 766 deaths (95% CrI 694-859) in the first 6 months of the campaign. If no vaccination had occurred, we estimate that an additional decrease of 10-20% in population mobility would have been required to maintain equivalent death and hospitalisation outcomes. We also found that early vaccination with CoronaVac was preferable to delayed vaccination using a product with higher efficacy.Interpretation:
SARS-CoV-2 transmission dynamics in the Dominican Republic were driven by a substantial accumulation of immunity during the first two years of the pandemic but, despite this, vaccination was essential in enabling a return to pre-pandemic mobility levels without considerable additional morbidity and mortality.Funding:
Medical Research Council, Wellcome Trust, Royal Society, US CDC and Australian National Health and Medical Research Council.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
País/Região como assunto:
Caribe ingles
/
Dominica
/
Republica dominicana
Idioma:
En
Revista:
Lancet Reg Health Am
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido
País de publicação:
Reino Unido