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Allergo-immunopathology mechanism of thymol-inhibiting airway remodeling in asthmatic mice by regulating TGF-ß/Smad3 pathway.
Zhang, Liyuan; Zhang, Wenna; Wang, Yanan; Cai, Pei; Li, Chaoran; Shi, Yan; Athari, Seyyed Shamsadin; Li, Ailing.
Afiliação
  • Zhang L; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China.
  • Zhang W; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China.
  • Wang Y; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China.
  • Cai P; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China.
  • Li C; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China.
  • Shi Y; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China.
  • Athari SS; Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Li A; Department of Respiratory and Critical Care Medicine, Xi'an International Medical Center Hospital, Xi'an, 710100, China; liailing98@outlook.com.
Allergol Immunopathol (Madr) ; 52(5): 51-58, 2024.
Article em En | MEDLINE | ID: mdl-39278851
ABSTRACT
Allergic asthma is an important public health problem and is a complicated respiratory sickness that is characterized by bronchial inflammation, bronchoconstriction, and breathlessness. Asthma is orchestrated by type 2 immune response and remodeling is one of the important outputted problem in chronic asthma. Thymol is a naturally occurring monocyclic phenolic, it has a series of biological properties, and its immunomodulatory and anti-remodeling effects on allergic asthma were evaluated. The OVA-LPS-induced asthmatic mice were treated with thymol. Methacholine challenge test, eosinophil count, and levels of IL-4, IL-5, IL-13, and IL-33 in bronchoalveolar lavage fluid, total and OVA-specific IgE levels in serum, remodeling factors, gene expression of TGF-ß, Smad2, Smad3, and lung histopathology were done. Treatment with thymol could control AHR, eosinophil percentage levels of Th2 cytokines and Igs, remodeling factors, expression of TGF-ß, Smad2 and Smad3 genes, inflammation, goblet cell hyperplasia, and mucus production in asthmatic mice. Thymol can control asthma pathogens and related remodeling and fibrosis bio-factors and can be a potential treatment of asthma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Timol / Transdução de Sinais / Fator de Crescimento Transformador beta / Modelos Animais de Doenças / Proteína Smad3 / Remodelação das Vias Aéreas / Camundongos Endogâmicos BALB C Limite: Animals / Female / Humans Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Singapura
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Timol / Transdução de Sinais / Fator de Crescimento Transformador beta / Modelos Animais de Doenças / Proteína Smad3 / Remodelação das Vias Aéreas / Camundongos Endogâmicos BALB C Limite: Animals / Female / Humans Idioma: En Revista: Allergol Immunopathol (Madr) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Singapura