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The Effects of Glibenclamide on Cognitive Performance, Quality of Life, and Emotional Aspects Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Controlled Trial.
Windlin, Isabela Costola; da Costa, Bruno Braga Sisnando; Mota Telles, João Paulo; Oliveira, Leonardo B; Koterba, Edwin; Yamaki, Vitor Nagai; Rabelo, Nicollas Nunes; Solla, Davi Jorge Fontoura; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha.
Afiliação
  • Windlin IC; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • da Costa BBS; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Mota Telles JP; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Oliveira LB; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil; Department of Neurosurgery, State University of Ponta Grossa, Ponta Grossa, Brazil.
  • Koterba E; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Yamaki VN; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Rabelo NN; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Solla DJF; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Teixeira MJ; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil.
  • Figueiredo EG; Department of Neurology, Hospital das Clínicas FMUSP, University of São Paulo, São Paulo, Brazil. Electronic address: ebgadelha@yahoo.com.
World Neurosurg ; 2024 Sep 14.
Article em En | MEDLINE | ID: mdl-39278541
ABSTRACT

BACKGROUND:

Aneurysmal subarachnoid hemorrhage (aSAH) is associated with a high incidence of long-term cognitive impairment, decreased quality of life (QoL), and psychiatric disorders. The effects of glibenclamide on such outcomes in the setting of aSAH are unknown.

OBJECTIVE:

To assess the impact of glibenclamide in patients with aSAH on cognitive performance, QoL, and emotional aspects.

METHODS:

Patients identified with aSAH were randomly allocated to receive 5 mg of glibenclamide for 21 days or placebo, starting within 96 hours of the ictus. After 6 months, patients were evaluated with Montreal Cognitive Assessment test (cognitive performance), Medical Outcomes Short-form Health Survey (QoL), and Hospital Anxiety and Depression Scale and Screen for Post-traumatic Stress Symptoms (emotional aspects).

RESULTS:

The mean Montreal Cognitive Assessment score was 22.5 ± 6.2. No statistically significant difference was found between groups, with a mean score of 21.7 ± 6.4 in the Glibenclamide group and 23.4 ± 6.2 in the placebo group (P = 0.392). A score <23 was observed in 16 patients (35.6%) and its frequency was similar between groups (P = 0.900). The most frequently impaired domains were Attention (N = 21/45; 46.7%) and Visuospatial (18/45; 40.0%). Impairment of each domain was similar between groups (P > 0.05). In each domain, the mean score was similar between groups (P > 0.05). The Hospital Anxiety and Depression Scale scores did not differ between groups (P > 0.05). The mean Screen for Post-traumatic Stress Symptoms score as well as the mean scores of its domains were similar between groups (P > 0.05).

CONCLUSIONS:

Glibenclamide did not improve cognitive performance, QoL, and emotional aspects after 6 months of follow-up of aSAH survivors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World Neurosurg Assunto da revista: NEUROCIRURGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: World Neurosurg Assunto da revista: NEUROCIRURGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos