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Gut-related molecules as potential biomarkers in patients with decompensated cirrhosis.
Barreto, Camila Marques de Alcântara; do Valle, Eliane Almeida; Moreira, Jessica Pronestino de Lima; E Silva, Katia Farias; Rosas, Siane Lopes Bittencourt; Santana, Patrícia Teixeira; Pittella, Ana Maria; Pereira, Gustavo; Fernandes, Flavia Ferreira; Perez, Renata de Mello; de Souza, Heitor Siffert Pereira.
Afiliação
  • Barreto CMA; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil; Bonsucesso Federal Hospital, Rio de Janeiro, 20950-003, Brazil.
  • do Valle EA; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil; Pedro Ernesto University Hospital, Rio de Janeiro, 20551-030, Brazil.
  • Moreira JPL; Department of Bromatology, Faculty of Pharmacy, Fluminense Federal University, Niterói, 24241-002, Brazil.
  • E Silva KF; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil; Pedro Ernesto University Hospital, Rio de Janeiro, 20551-030, Brazil.
  • Rosas SLB; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.
  • Santana PT; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil.
  • Pittella AM; Quinta D'Or Hospital, Rio de Janeiro, 20941-150, Brazil.
  • Pereira G; Bonsucesso Federal Hospital, Rio de Janeiro, 20950-003, Brazil.
  • Fernandes FF; Pedro Ernesto University Hospital, Rio de Janeiro, 20551-030, Brazil.
  • Perez RM; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil; D'Or Institute for Research and Education (IDOR), Botafogo, Rio de Janeiro, 22281-100, Brazil.
  • de Souza HSP; Department of Clinical Medicine, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-913, Brazil; D'Or Institute for Research and Education (IDOR), Botafogo, Rio de Janeiro, 22281-100, Brazil. Electronic address: hsouza@hucff.ufrj.br.
Ann Hepatol ; 30(1): 101567, 2024 Sep 12.
Article em En | MEDLINE | ID: mdl-39276985
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

Microbial translocation contributes to cirrhosis progression and complications. This study aims to investigate whether molecules related to intestinal permeability or microbial translocation can serve as prognostic biomarkers in patients with decompensated cirrhosis. MATERIALS AND

METHODS:

We prospectively evaluated hospitalized patients with decompensated cirrhosis for liver function, complications during hospitalization, in-hospital mortality, composite outcomes of in-hospital mortality and complications, 12-month mortality, and survival rates. Blood samples were collected upon admission, and 1,3 beta-d-glucan, zonulin, calprotectin, and lipopolysaccharide-binding protein were measured using commercial kits.

RESULTS:

Ninety-one patients with decompensated cirrhosis were enrolled. The mean age was 58 ± 12 years; 57% were male. The three main cirrhosis etiologies were hepatitis C (35%), alcohol (25%), and non-alcoholic steatohepatitis (17%). In terms of liver function, 52% were Child C, and 68% had model for end-stage liver disease ≥15. The in-hospital and one-year mortality rates were 31% and 57%, respectively. Child-Pugh, 1,3 beta-glucan, and model for end-stage liver disease were positively correlated; zonulin was associated with complications during hospitalization (acute kidney injury) and composite outcomes, and calprotectin was associated with all outcomes except 12-month mortality.

CONCLUSIONS:

Serum calprotectin and zonulin levels emerge as noninvasive prognostic biomarkers for potentially unfavorable outcomes in patients with decompensated cirrhosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: México