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Six and twelve-month respiratory outcomes in a cohort of severe and critical COVID-19 survivors: A prospective monocentric study in Latin America.
Fernández-Trujillo, Liliana; Galindo-Sánchez, Juan Sebastián; Cediel, Angie; García, Carlos A; Morales, Eliana I; Largo, Jessica; Amezquita-Dussan, María A.
Afiliação
  • Fernández-Trujillo L; Department of Internal Medicine, Pulmonology Service, Fundación Valle del Lili, Cali, Colombia.
  • Galindo-Sánchez JS; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.
  • Cediel A; Clinical Research Center, Fundación Valle del Lili, Cali, Colombia.
  • García CA; Department of Diagnostic Imaging Fundación Valle del Lili, Cali, Colombia.
  • Morales EI; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.
  • Largo J; Department of Diagnostic Imaging Fundación Valle del Lili, Cali, Colombia.
  • Amezquita-Dussan MA; Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.
SAGE Open Med ; 12: 20503121241275369, 2024.
Article em En | MEDLINE | ID: mdl-39263637
ABSTRACT

Introduction:

Severe COVID-19 can result in long-term sequelae known as "chronic COVID," characterized by a wide range of persistent physical and mental symptoms. Chest imaging and pulmonary function test alterations have been observed in recovered patients. Most studies focus on up to a 3-month follow-up after symptom onset or hospital discharge, with few reports on long-term follow-up and limited evidence regarding disease progression in Latin America.

Methods:

This study aims to describe the clinical characteristics and changes in pulmonary function, imaging, and quality of life in severe and critical COVID-19 patients requiring ICU admission in a high-complexity hospital in Latin America. A prospective cohort of survivors underwent clinical, radiological, pulmonary function, and quality of life assessments 6 and 12 months post-discharge.

Results:

One hundred twelve patients were included, all of whom attended the 6-month follow-up, and 99 returned for the 12-month follow-up. Most subjects had no previous respiratory symptoms or significant medical history. At the end of the follow-up period, 74% of the patients showed interstitial infiltrates in chest tomography and a higher frequency of fibroatelectatic tracts and parenchymal bands. Pulmonary function tests returned to normal ranges, except for carbon monoxide diffusion, but no altered scores were reported in the questionnaires.

Conclusion:

Despite residual radiological findings, most parameters studied in severe and critical COVID-19 survivors improved over the 12-month follow-up period. Regardless of the imaging abnormalities, the improvement in variables such as symptomatic relief and normal pulmonary function suggests that these alterations are transient. Carbon monoxide diffusion did not normalize by the end of the follow-up, which is consistent with the abnormalities reported in multiple studies, indicating a potential disease-related pattern.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: SAGE Open Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: SAGE Open Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido