The effectiveness of Lactobacillus rhamnosus GG in the treatment of infantile colic: a systematic review and meta-analysis.
Transl Pediatr
; 13(8): 1415-1424, 2024 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-39263298
ABSTRACT
Background:
Infantile colic is common in pediatric patients, yet few probiotics effectively treat this condition. The efficacy of Lactobacillus rhamnosus GG (LGG) in managing colic remains unclear. In this meta-analysis, we aimed to evaluate the effectiveness of LGG in treating infantile colic.Methods:
We searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases from their inception until January 2024. We used Version 2 of the Cochrane tool (ROB 2) to assess the risk of bias in randomized trials. Meta-analysis was conducted using RevMan 5.3 software. The inclusion criteria followed the PICOS framework (I)participants:
infants with colic; (II) intervention LGG administration at any dose; (III) control placebo or no treatment; (IV)outcomes:
primary outcome was crying or fussing time (minutes/day) at the end of the intervention, secondary outcomes included fecal calprotectin content (µg/g) and adverse events; (V) Study type randomized controlled trials.Results:
Four studies involving 168 infants with colic were included. The meta-analysis indicated that LGG significantly reduced daily crying time [mean difference (MD) =-32.59 minutes; 95% confidence interval (CI) -43.23 to -21.96; P<0.001] and fecal calprotectin content (MD =-103.28 µg/g; 95% CI -149.30 to -7.26; P<0.001). Only one study reported adverse events.Conclusions:
LGG is effective in treating infantile colic. Further studies are needed to examine the effects of different doses, administration schedules, and durations of LGG treatment in infants with varying feeding methods.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Transl Pediatr
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
China