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In vitro exposure to butylparaben impairs the integrity and size of ovarian follicles in a bovine model.
da Costa, Ivana Regina; Erthal, Rafaela Pires; da Silva Scarton, Suellen Ribeiro; Gonzalez, Suellen Miguez; Cerezetti, Marcela Bortoletto; Morotti, Fábio; Seneda, Marcelo Marcondes; Fernandes, Glaura Scantamburlo Alves.
Afiliação
  • da Costa IR; Department of General Biology, Biological Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • Erthal RP; Department of General Pathology, Biological Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • da Silva Scarton SR; Department of General Pathology, Biological Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • Gonzalez SM; Department of Veterinary Clinics, Agrarian Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • Cerezetti MB; Department of Veterinary Clinics, Agrarian Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • Morotti F; Department of Veterinary Clinics, Agrarian Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • Seneda MM; Department of Veterinary Clinics, Agrarian Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil.
  • Fernandes GSA; Department of General Biology, Biological Sciences Center, State University of Londrina- UEL, Rodovia Celso Garcia Cid, PR 445, Londrina, 86057-970, Paraná, Brazil. glaura@uel.br.
Vet Res Commun ; 2024 Sep 11.
Article em En | MEDLINE | ID: mdl-39259415
ABSTRACT
There is a growing regulatory and scientific interest in the studies of environmental substances that are capable of interfering with the reproductive system. Among them, parabens stand out due to their widespread use and frequent detection as contaminants in human tissues and biological fluids. Therefore, we evaluated the toxic effects of butylparaben on the viability and follicular staging of bovine ovarian follicles in vitro. Fragments of ovaries from five cyclic bovine females were cultured for 44 h in a minimal essential medium (MEM; control) or MEM supplemented with 50 µg/mL and 100 µg/mL of butylparaben (BP 50 and BP 100 groups, respectively). The ovarian fragments were subjected to follicular staging, morphological analysis, morphometric analysis, estradiol analysis and oxidative profiling. No significant changes were observed between the experimental groups in follicular staging, estradiol analysis and oxidative profile analysis. However, the BP 50 group showed a significant decrease in the number of intact ovarian follicles. Moreover, a decrease in the follicular and oocyte diameters was observed in the groups that were exposed to butylparaben. In conclusion, butylparaben impairs the integrity and size of ovarian follicles in an in vitro bovine model, but does not affect the oxidative profile and steroidogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Vet Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça