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mRNA-1273 vaccination induces polyfunctional memory CD4 and CD8 T cell responses in patients with solid cancers undergoing immunotherapy or/and chemotherapy.
Gangaev, Anastasia; van Sleen, Yannick; Brandhorst, Nicole; Hoefakker, Kelly; Prajapati, Bimal; Singh, Amrita; Boerma, Annemarie; van der Heiden, Marieke; Oosting, Sjoukje F; van der Veldt, Astrid A M; Hiltermann, T Jeroen N; GeurtsvanKessel, Corine H; Dingemans, Anne-Marie C; Smit, Egbert F; de Vries, Elisabeth G E; Haanen, John B A G; Kvistborg, Pia; van Baarle, Debbie.
Afiliação
  • Gangaev A; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
  • van Sleen Y; Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, Netherlands.
  • Brandhorst N; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
  • Hoefakker K; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
  • Prajapati B; Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, Netherlands.
  • Singh A; Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, Netherlands.
  • Boerma A; Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, Netherlands.
  • van der Heiden M; Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, Netherlands.
  • Oosting SF; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • van der Veldt AAM; Department of Medical Oncology and Radiology & Nuclear Medicine, Erasmus Medical Center (MC)-Cancer Institute, Rotterdam, Netherlands.
  • Hiltermann TJN; Department of Pulmonary Diseases, University Medical Centre Groningen, Groningen, Netherlands.
  • GeurtsvanKessel CH; Department of Viroscience, Erasmus Medical Center (MC) Cancer Institute, University Medical Centre, Rotterdam, Netherlands.
  • Dingemans AC; Department of Respiratory Medicine, Erasmus Medical Centre, Rotterdam, Netherlands.
  • Smit EF; Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
  • de Vries EGE; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • Haanen JBAG; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
  • Kvistborg P; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
  • van Baarle D; Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen, Groningen, Netherlands.
Front Immunol ; 15: 1447555, 2024.
Article em En | MEDLINE | ID: mdl-39257577
ABSTRACT

Introduction:

Research has confirmed the safety and comparable seroconversion rates following SARS-CoV-2 vaccination in patients with solid cancers. However, the impact of cancer treatment on vaccine-induced T cell responses remains poorly understood.

Methods:

In this study, we expand on previous findings within the VOICE trial by evaluating the functional and phenotypic composition of mRNA-1273-induced T cell responses in patients with solid tumors undergoing immunotherapy, chemotherapy, or both, compared to individuals without cancer. We conducted an ELISpot analysis on 386 participants to assess spike-specific T cell responses 28 days after full vaccination. Further in-depth characterization of using flow cytometry was performed on a subset of 63 participants to analyze the functional phenotype and differentiation state of spike-specific T cell responses.

Results:

ELISpot analysis showed robust induction of spike-specific T cell responses across all treatment groups, with response rates ranging from 75% to 80%. Flow cytometry analysis revealed a distinctive cytokine production pattern across cohorts, with CD4 T cells producing IFNγ, TNF, and IL-2, and CD8 T cells producing IFNγ, TNF, and CCL4. Variations were observed in the proportion of monofunctional CD4 T cells producing TNF, particularly higher in individuals without cancer and patients treated with chemotherapy alone, while those treated with immunotherapy or chemoimmunotherapy predominantly produced IFNγ. Despite these differences, polyfunctional spike-specific memory CD4 and CD8 T cell responses were comparable across cohorts. Notably, immunotherapy-treated patients exhibited an expansion of spike-specific CD4 T cells with a terminally differentiated effector memory phenotype.

Discussion:

These findings demonstrate that systemic treatment in patients with solid tumors does not compromise the quality of polyfunctional mRNA-1273-induced T cell responses. This underscores the importance of COVID-19 vaccination in patients with solid cancers undergoing systemic treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / SARS-CoV-2 / COVID-19 / Vacina de mRNA-1273 contra 2019-nCoV / Células T de Memória / Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Linfócitos T CD8-Positivos / SARS-CoV-2 / COVID-19 / Vacina de mRNA-1273 contra 2019-nCoV / Células T de Memória / Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Holanda País de publicação: Suíça