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TARGET based m6A methylation-related genes predict prognosis relapsed B-cell acute lymphoblastic leukemia.
Qiu, Kun-Yin; Liao, Xiong-Yu; Fang, Jian-Pei; Zhou, Dun-Hua.
Afiliação
  • Qiu KY; Department of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, P.R. China.
  • Liao XY; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P.R. China.
  • Fang JP; Department of Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, P.R. China.
  • Zhou DH; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P.R. China.
BMC Pediatr ; 24(1): 574, 2024 Sep 10.
Article em En | MEDLINE | ID: mdl-39251964
ABSTRACT

PURPOSE:

The current study aims to investigate the significance of N6-methyladenosine (m6A) methylationrelated genes in the clinical prognosis of childhood relapsed B-cell acute lymphoblastic leukemia (B-ALLL) patient.

METHODS:

Transcriptome data and corresponding clinical data on m6A methylation-related genes (including 20 genes) were obtained from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) database.

RESULTS:

The bone marrow (BM) samples of 134 newly diagnosed (naive) and 116 relapsed B-ALL from TARGET were enrolled in the current study. Three genes (FTO, HNRNPC, RBM15B) showed significant up-regulation in relapsed B-ALL compared with that in naive B-ALL.The three genes had a significantly worse survival (P < 0.05). The LASSO Cox regression model was used to select the most predictive genes as prognostic indicators, and YTHDC1 and FTO were identified as prognostic factors for relapsed B-ALL. Finally, the results of multivariate regression analysis showed that the risk score of m6A methylation-related genes was an independent prognostic factor in relapsed B-ALL (P < 0.05).

CONCLUSION:

We found that the expression levels of m6A methylation-related genes were different in naive and relapsed patients with B-ALL and correlated with survival and prognosis.This implies that m6A methylation-related genes may be promising prognostic indicators or therapeutic targets for relapsed B-ALL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Adenosina / Proteínas de Ligação a RNA / Dioxigenase FTO Dependente de alfa-Cetoglutarato / Fatores de Processamento de RNA Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: BMC Pediatr Assunto da revista: PEDIATRIA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Adenosina / Proteínas de Ligação a RNA / Dioxigenase FTO Dependente de alfa-Cetoglutarato / Fatores de Processamento de RNA Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: BMC Pediatr Assunto da revista: PEDIATRIA Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido