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3D printing of strontium-enriched biphasic calcium phosphate scaffolds for bone regeneration.
Oliveira, Rodrigo L M S; Ferraz, Marcos C; Cardoso, Lais Medeiros; Li, Zhongrui; Albers, Ana Paula F; Bottino, Marco C; Trichês, Eliandra S.
Afiliação
  • Oliveira RLMS; Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil.
  • Ferraz MC; Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil.
  • Cardoso LM; Department of Dental Materials and Prosthodontics, Araraquara School of Dentistry, Sao Paulo State University - UNESP, 14801-385, Araraquara, SP, Brazil; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Li Z; Electron Microbeam Analysis Laboratory, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Albers APF; Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil.
  • Bottino MC; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: mbottino@umich.edu.
  • Trichês ES; Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil; Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic addre
J Mech Behav Biomed Mater ; 160: 106717, 2024 Sep 03.
Article em En | MEDLINE | ID: mdl-39243571
ABSTRACT
Calcium phosphate (CaP) scaffolds doping with therapeutic ions are one of the focuses of recent bone tissue engineering research. Among the therapeutic ions, strontium stands out for its role in bone remodeling. This work reports a simple method to produce Sr-doped 3D-printed CaP scaffolds, using Sr-doping to induce partial phase transformation from ß-tricalcium phosphate (ß-TCP) to hydroxyapatite (HA), resulting in a doped biphasic calcium phosphate (BCP) scaffold. Strontium carbonate (SrCO3) was incorporated in the formulation of the 3D-printing ink, studying ß-TCPSrO mass ratios of 1000, 955, and 9010 (named as ß-TCP, ß-TCP/5-Sr, and ß-TCP/10-Sr, respectively). Adding SrCO3 in the 3D-printing ink led to a slight increase in viscosity but did not affect its printability, resulting in scaffolds with a high printing fidelity compared to the computational design. Interestingly, Sr was incorporated into the lattice structure of the scaffolds, forming hydroxyapatite (HA). No residual SrO or SrCO3 were observed in the XRD patterns of any composition, and HA was the majority phase of the ß-TCP/10-Sr scaffolds. The addition of Sr increased the compression strength of the scaffolds, with both ß-TCP/5-Sr and ß-TCP/10-Sr performing better than the ß-TCP. Overall, ß-TCP/5-Sr presented higher mineralized nodules and mechanical strength, while ß-TCP scaffolds presented superior cell viability. The incorporation of SrCO3 in the ink formulation is a viable method to obtain Sr-BCP scaffolds. Thus, this approach could be explored with other CaP scaffolds aiming to optimize their performance and the addition of alternative therapeutic ions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Mech Behav Biomed Mater Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Mech Behav Biomed Mater Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda