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Genomic insights into a Proteus mirabilis strain inducing avian cellulitis.
de Oliva, Bruno Henrique Dias; do Nascimento, Arthur Bossi; de Oliveira, João Paulo; Guidone, Gustavo Henrique Migliorini; Schoeps, Beatriz Lernic; Silva, Luana Carvalho; Barbosa, Mario Gabriel Lopes; Montini, Victor Hugo; de Oliveira Junior, Admilton Gonçalves; Rocha, Sérgio Paulo Dejato.
Afiliação
  • de Oliva BHD; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • do Nascimento AB; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • de Oliveira JP; Laboratory of Microbial Biotechnology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil.
  • Guidone GHM; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • Schoeps BL; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • Silva LC; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • Barbosa MGL; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • Montini VH; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil.
  • de Oliveira Junior AG; Laboratory of Microbial Biotechnology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil.
  • Rocha SPD; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid, PO-BOX 6001, Londrina, 86051-980, Paraná, Brazil. rochaspd@uel.br.
Braz J Microbiol ; 2024 Sep 05.
Article em En | MEDLINE | ID: mdl-39235714
ABSTRACT
Proteus mirabilis, a microorganism distributed in soil, water, and animals, is clinically known for causing urinary tract infections in humans. However, recent studies have linked it to skin infections in broiler chickens, termed avian cellulitis, which poses a threat to animal welfare. While Avian Pathogenic Escherichia coli (APEC) is the primary cause of avian cellulitis, few cases of P. mirabilis involvement are reported, raising questions about the factors facilitating such occurrences. This study employed a pan-genomic approach to investigate whether unique genes exist in P. mirabilis strains causing avian cellulitis. The genome of LBUEL-A33, a P. mirabilis strain known to cause this infection, was assembled, and compared with other P. mirabilis strains isolated from poultry and other sources. Additionally, in silico serogroup analysis was conducted. Results revealed numerous genes unique to the LBUEL-A33 strain. No function in cellulitis was identified for these genes, and in silico investigation of the virulence potential of LBUEL-A33's exclusive proteins proved inconclusive. These findings support that multiple factors are necessary for P. mirabilis to cause avian cellulitis. Furthermore, this species likely employs its own unique arsenal of virulence factors, as many identified mechanisms are analogous to those of E. coli. While antigenic gene clusters responsible for serogroups were identified, no clear trend was observed, and the gene cluster of LBUEL-A33 did not show homology with any sequenced Proteus serogroups. These results reinforce the understanding that this disease is multifactorial, necessitating further research to unravel the mechanisms and underpin the development of control and prevention strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Braz J Microbiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Braz J Microbiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil