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Alteration of lncRNA RHPN1-AS1 predicts clinical prognosis and regulates the progression of bladder cancer via modulating miR-485-5p.
Zhou, Jingmin; Xu, Jinshan; Cheng, Lin; Li, Shuhui; Jiang, Deqi; Zhang, Jianchao; Sheng, Yulong.
Afiliação
  • Zhou J; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
  • Xu J; Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China.
  • Cheng L; Department of Urology Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, China.
  • Li S; Department of Joint Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, China.
  • Jiang D; Department of Urology Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, China.
  • Zhang J; Department of Urology Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, China.
  • Sheng Y; Department of Interventional Medicine, The Affiliated Hospital of Qingdao University (Pingdu), Qingdao, Shandong, China.
Int J Biol Markers ; : 3936155241281076, 2024 Sep 05.
Article em En | MEDLINE | ID: mdl-39233606
ABSTRACT

BACKGROUND:

Exploring effect biomarkers that monitor tumor progression and predict the prognosis could benefit the clinical management of bladder cancer and improve the postoperative life of patients. This study aimed to estimate the function of long non-coding (lnc)RNA RHPN1-AS1 (RHPN1-AS1) in bladder cancer and the potential molecular mechanism.

METHODS:

The expression of RHPN1-AS1 was evaluated in bladder cancer tissues from 115 patients and cells by polymerase chain reaction. The clinical significance of RHPN1-AS1 was assessed and its effect was also estimated in cell proliferation, migration, and invasion. The underlying molecular mechanism was explored by the dual-luciferase reporter assay.

RESULTS:

The expression of RHPN1-AS1 was 2.91-fold elevated in bladder cancer, which showed a close correlation with advanced tumor node metastasis stage (P = 0.013) and the presence of lymph node metastasis (P = 0.018). RHPN1-AS1 also served as a poor prognostic indicator (hazard ratio = 2.563) for bladder cancer. The knockdown of RHPN1-AS1 significantly suppressed the proliferation and metastasis ability of bladder cancer cells. Moreover, miR-485-5p was found to mediate the function of RHPN1-AS1 in bladder cancer, which was considered the underlying regulatory mechanism.

CONCLUSIONS:

RHPN1-AS1 serves as a prognostic biomarker and tumor promoter in bladder cancer via modulating miR-485-5p, which might be a reliable target of bladder cancer therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Biol Markers Assunto da revista: BIOQUIMICA / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Biol Markers Assunto da revista: BIOQUIMICA / NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos