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Associations between Parenting and Cognitive and Language Abilities at 2 Years of Age Depend on Prenatal Exposure to Disadvantage.
Leverett, Shelby D; Brady, Rebecca G; Tooley, Ursula A; Lean, Rachel E; Tillman, Rebecca; Wilson, Jillian; Ruscitti, Michayla; Triplett, Regina L; Alexopoulos, Dimitrios; Gerstein, Emily D; Smyser, Tara A; Warner, Barbara; Luby, Joan L; Smyser, Christopher D; Rogers, Cynthia E; Barch, Deanna M.
Afiliação
  • Leverett SD; Division of Biology & Biomedical Sciences, Neurosciences Program, Washington University in Saint Louis, St Louis, MO; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO. Electronic address: leverett.s@wustl.edu.
  • Brady RG; Division of Biology & Biomedical Sciences, Neurosciences Program, Washington University in Saint Louis, St Louis, MO.
  • Tooley UA; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Lean RE; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Tillman R; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Wilson J; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Ruscitti M; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Triplett RL; Department of Neurology, Washington University in Saint Louis, St Louis, MO.
  • Alexopoulos D; Department of Neurology, Washington University in Saint Louis, St Louis, MO.
  • Gerstein ED; Department of Psychological Sciences, University of Missouri-St. Louis, St Louis, MO.
  • Smyser TA; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Warner B; Department of Pediatrics, Washington University in Saint Louis, St Louis, MO.
  • Luby JL; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Smyser CD; Department of Neurology, Washington University in Saint Louis, St Louis, MO.
  • Rogers CE; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO.
  • Barch DM; Department of Psychiatry, Washington University in Saint Louis, St Louis, MO; Department of Psychological and Brain Sciences, Washington University in St. Louis, St Louis, MO; Department of Radiology, Washington University in St. Louis, St Louis, MO.
J Pediatr ; 276: 114289, 2024 Sep 02.
Article em En | MEDLINE | ID: mdl-39233119
ABSTRACT

OBJECTIVE:

To investigate whether parenting or neonatal brain volumes mediate associations between prenatal social disadvantage (PSD) and cognitive/language abilities and whether these mechanisms vary by level of disadvantage. STUDY

DESIGN:

Pregnant women were recruited prospectively from obstetric clinics in St Louis, Missouri. PSD encompassed access to social (eg, education) and material (eg, income to needs, health insurance, area deprivation, and nutrition) resources during pregnancy. Neonates underwent brain magnetic resonance imaging. Mother-child dyads (n = 202) returned at age 1 year for parenting observations and at age 2 years for cognition/language assessments (Bayley Scales of Infant and Toddler Development, Third Edition). Generalized additive and mediation models tested hypotheses.

RESULTS:

Greater PSD associated nonlinearly with poorer cognitive/language scores. Associations between parenting and cognition/language were moderated by disadvantage, such that supportive and nonsupportive parenting behaviors related only to cognition/language in children with lesser PSD. Parenting mediation effects differed by level of disadvantage both supportive and nonsupportive parenting mediated PSD-cognition/language associations in children with lesser disadvantage, but not in children with greater disadvantage. PSD-associated reductions in neonatal subcortical grey matter (ß = 0.19; q = 0.03), white matter (ß = 0.23; q = 0.02), and total brain volume (ß = 0.18; q = 0.03) were associated with lower cognition, but did not mediate the associations between PSD and cognition.

CONCLUSIONS:

Parenting moderates and mediates associations between PSD and early cognition and language, but only in families with less social disadvantage. These findings, although correlational, suggest that there may be a critical threshold of disadvantage, below which mediating or moderating factors become less effective, highlighting the importance of reducing disadvantage as primary prevention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article País de publicação: Estados Unidos