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Epstein-Barr virus-associated post-transplant smooth muscle tumours in a kidney transplant patient.
Cobeñas, Carlos J; Pereyra, Priscila; Spizzirri, Ana Paula; Gauto Santacruz, Cristina; Del Carmen Suarez, Angela; Altamirano, Eugenia; Pérez, Paula; Tello, Nicolas.
Afiliação
  • Cobeñas CJ; Nephrology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Buenos Aires, Argentina. carlos.cobenas@hotmail.com.
  • Pereyra P; Nephrology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Buenos Aires, Argentina.
  • Spizzirri AP; Nephrology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Buenos Aires, Argentina.
  • Gauto Santacruz C; Nephrology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Buenos Aires, Argentina.
  • Del Carmen Suarez A; Nephrology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Buenos Aires, Argentina.
  • Altamirano E; Pathology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Argentina.
  • Pérez P; Pathology Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Argentina.
  • Tello N; Neurosurgery Department, Hospital de Niños "Sup. Sor María Ludovica", La Plata, Argentina.
Pediatr Nephrol ; 2024 Sep 04.
Article em En | MEDLINE | ID: mdl-39230732
ABSTRACT
We report on a 14-year-old girl who developed post-transplantation smooth muscle tumours (PTSMT) located in the spleen, lungs, liver, and central nervous system (CNS), 4 years after kidney transplantation. She was asymptomatic, and the disease was detected during the work-up for a urinary tract infection. Diagnosis was performed by the analysis of a tissue specimen, through the biopsy of a lung tumour, which revealed a proliferation of spindle-shaped cells which were positive for actin and vimentin. In situ hybridization studies were positive for Epstein-Barr virus, and her serologic status was negative prior to transplantation. We reduced immunosuppression by stopping mycophenolate and switching tacrolimus for sirolimus. After 18 months of follow-up, she remains asymptomatic, and the CNS tumour reduced its diameter from 24 × 21 mm to 14 × 13 mm. PTSMT should be considered in the differential diagnosis of transplanted patients who develop neoplastic complications associated with immunosuppression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pediatr Nephrol Assunto da revista: NEFROLOGIA / PEDIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha