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Disentangling the relationship between biological age and frailty in community-dwelling older Mexican adults.
Fermín-Martínez, Carlos A; Ramírez-García, Daniel; Antonio-Villa, Neftali Eduardo; López-Teros, Miriam Teresa; Seiglie, Jacqueline A; Pérez, Roberto Carlos Castrejón; Peña, Carmen García; Gutiérrez-Robledo, Luis Miguel; Bello-Chavolla, Omar Yaxmehen.
Afiliação
  • Fermín-Martínez CA; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.
  • Ramírez-García D; MD/PhD (PECEM) Program, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Antonio-Villa NE; Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.
  • López-Teros MT; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Seiglie JA; Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Pérez RCC; Universidad Iberoamericana, Mexico City, Mexico.
  • Peña CG; Dirección de Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán, Mexico City, Mexico.
  • Gutiérrez-Robledo LM; Diabetes Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Bello-Chavolla OY; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
medRxiv ; 2024 Aug 20.
Article em En | MEDLINE | ID: mdl-39228729
ABSTRACT

OBJECTIVE:

Older adults have heterogeneous aging rates. Here, we explored the impact of biological age (BA) and accelerated aging on frailty in community-dwelling older adults.

METHODS:

We assessed 735 community-dwelling older adults from the Coyocan Cohort. BA was measured using AnthropoAge, accelerated aging with AnthropoAgeAccel, and frailty using both Fried's phenotype and the frailty index. We explored the association of BA and accelerated aging (AnthropoAgeAccel ≥0) with frailty at baseline and characterized the impact of both on body composition and physical function. We also explored accelerated aging as a risk factor for frailty progression after 3-years of follow-up.

RESULTS:

Older adults with accelerated aging have higher frailty prevalence and indices, lower handgrip strength and gait speed. AnthropoAgeAccel was associated with higher frailty indices (ß=0.0053, 95%CI 0.0027-0.0079), and increased odds of frailty at baseline (OR 1.16, 95%CI 1.09-1.25). We observed a sexual dimorphism in body composition and physical function linked to accelerated aging in non-frail participants; however, this dimorphism was absent in pre-frail/frail participants. Accelerated aging at baseline was associated with higher risk of frailty progression over time (OR 1.74, 95%CI 1.11-2.75).

CONCLUSIONS:

Despite being intertwined, biological accelerated aging is largely independent of frailty in community-dwelling older adults.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: MedRxiv Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: MedRxiv Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos