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The descriptive epidemiology of adverse events following two doses of mRNA COVID-19 vaccination in Curaçao, the Caribbean.
Lambo, Jonathan; Keli, Sirving; Kaplan, Shaheen Khan; Njideaka-Kevin, Temiloluwa; Arja, Sireesha Bala; Khedir Omer Altahir, Alaa; Olonade, Itunu; Kumar, Rohit.
Afiliação
  • Lambo J; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Keli S; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Kaplan SK; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Njideaka-Kevin T; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Arja SB; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Khedir Omer Altahir A; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Olonade I; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
  • Kumar R; Department of Epidemiology and Evidence-based Medicine, Avalon University School of Medicine, Willemstad, Curaçao.
Infect Dis (Lond) ; : 1-13, 2024 Sep 03.
Article em En | MEDLINE | ID: mdl-39226235
ABSTRACT

BACKGROUND:

BNT162b2 and mRNA-1273 COVID-19 vaccines have been used for mass vaccinations in Curaçao, the Caribbean but information on adverse events (AEs)in this population is unavailable. This study describes the characteristics of vaccinees that incurred AEs, explores the associations between AEs by vaccine and doses, and estimates the rate of AEs.

METHODS:

Vaccination and AEs data for all persons of age 5 years (range 5-105 years) and older who received two doses of COVID-19 vaccine at 71 centres in Curaçao between February 24, 2021, and April 5, 2023, were included in this retrospective observational study.

RESULTS:

The vaccines differed significantly in the frequency distribution of vaccinees by age, age groups, sex, AEs, and prior COVID-19 infection. Occurrence of AEs was strongly associated with mRNA vaccine brand, sex, number of doses, but not with age, age group, and prior COVID-19 infection. Of 209,720 doses, 84 persons (0.04%) incurred AEs following two doses of mRNA vaccines (overall rate of 40.1 per 100,000 persons (95% CI 32.4-49.6). AEs were also significantly higher in females compared to males.AE rates associated with BNT162b2, and mRNA-1273 vaccines were low, but BNT162b2 vaccinees incurred substantially significantly higher AE rates (58.3 per 100,000 persons, 95% CI 45.4-74.9) than mRNA-1273 vaccinees (21.9 per 100,000 persons, 95% CI 14.6-32.8). mRNA-1273 vaccine was associated with a significantly lower risk of AEs.

CONCLUSIONS:

AE reporting varied by age, sex, and vaccine used as well as the number of doses. Future studies with follow-up and longer-term reporting of AEs should be conducted.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Antillas holandesas / Caribe ingles Idioma: En Revista: Infect Dis (Lond) Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Antillas holandesas / Caribe ingles Idioma: En Revista: Infect Dis (Lond) Ano de publicação: 2024 Tipo de documento: Article País de publicação: Reino Unido