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Urinary Thioproline and Thioprolinyl Glycine as Specific Biomarkers of Formaldehyde Exposure in Humans.
Pan, Guanrui; Au, Chun-Kit; Ham, Yat-Hing; Yu, Jian Zhen; Cai, Zongwei; Chan, Wan.
Afiliação
  • Pan G; Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China.
  • Au CK; Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China.
  • Ham YH; Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China.
  • Yu JZ; Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, China.
  • Cai Z; Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Kowloon , Hong Kong SAR, China.
  • Chan W; Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon , Hong Kong SAR, China.
Environ Sci Technol ; 58(37): 16368-16375, 2024 Sep 17.
Article em En | MEDLINE | ID: mdl-39223712
ABSTRACT
Assessment of personal formaldehyde (FA) exposure is most commonly carried out using formate as a biomarker, as it is the major product from FA metabolism. However, formate could also have originated from the metabolism of other endogenous and exogenous substances or from dietary intake, which may give rise to overestimated results with regard to FA exposure. We have developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with an isotope-dilution method for rigorous quantitation of two major urinary FA conjugation products thioproline (SPro) and thioprolinyl glycine (SPro-Gly), formed in the reaction between FA and endogenous cysteine or cysteinyl glycine, respectively, as marker molecules to assess personal FA exposure. Using this newly developed method, we measured the FA exposure levels in cigarette smokers, occupants of a chemistry research laboratory and typical domestic household, and visitors to a Chinese temple with a Pearson correlation coefficient greater than 0.94, showing a strong linear correlation between urinary adduct levels and the airborne FA level. It is believed that quantitation of urinary SPro and SPro-Gly may represent a noninvasive, interference-free method for assessing personal FA exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Formaldeído Limite: Humans Idioma: En Revista: Environ Sci Technol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Formaldeído Limite: Humans Idioma: En Revista: Environ Sci Technol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos