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Efficacy, safety, and impact of fluorescein in frameless stereotactic needle biopsies - a case series.
Dellaretti, Marcos; de Lima, Franklin Bernardes Faraj; de Sena, Pedro Henrique Velasco Pondé; Figueiredo, Hian Penna Gavazza; Albuquerque, João Pedro Santos; Gomes, Fernando Cotrim; Dias Faria, Barbara Caroline; de Almeida, Júlio César.
Afiliação
  • Dellaretti M; Santa Casa de BH e Faculdade Santa Casa BH, Belo Horizonte, MG, Brasil. mdellaretti@mac.com.
  • de Lima FBF; Santa Casa de BH e Faculdade Santa Casa BH, Belo Horizonte, MG, Brasil.
  • de Sena PHVP; Santa Casa de BH e Faculdade Santa Casa BH, Belo Horizonte, MG, Brasil.
  • Figueiredo HPG; Santa Casa de BH e Faculdade Santa Casa BH, Belo Horizonte, MG, Brasil.
  • Albuquerque JPS; Santa Casa de BH e Faculdade Santa Casa BH, Belo Horizonte, MG, Brasil.
  • Gomes FC; Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
  • Dias Faria BC; Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil.
  • de Almeida JC; Santa Casa de BH e Faculdade Santa Casa BH, Belo Horizonte, MG, Brasil.
Neurosurg Rev ; 47(1): 523, 2024 Sep 03.
Article em En | MEDLINE | ID: mdl-39223420
ABSTRACT
Stereotactic needle biopsy stands as a crucial method for diagnosing intracranial lesions unsuitable for surgical intervention. Nonetheless, the potential for sampling errors lead to innovative approaches to enhance diagnostic precision. This study contrasts the outcomes of patients undergoing fluorescein-assisted frameless stereotactic needle biopsy with those receiving traditional biopsies to evaluate the impact on diagnostic accuracy and safety. This study included patients with contrast-enhancing intracranial lesions, comprising a prospective group undergoing fluorescein-assisted biopsies and a retrospective group undergoing conventional biopsies at the same institution. We've collected data on demographics, procedural specifics, diagnostic outcomes, and postoperative events. A comparative analysis involved 43 patients who received fluorescein-assisted biopsies against 77 patients who underwent conventional biopsies. The average age was 60.5 years. The fluorescein group exhibited a 93% success rate in diagnosis, markedly higher than the 70.1% in the non-fluorescein group (OR = 5.67; 95%IC 1.59-20.24; p < 0.01). The rate of complications was statistically similar across both cohorts. Despite its established value, stereotactic needle biopsy is susceptible to inaccuracies and complications. The application of fluorescence-based adjuncts like 5-ALA and fluorescein has been investigated to improve diagnostic fidelity and reduce risks. These technologies potentially minimize the necessity for multiple biopsies, decrease surgical duration, and provide immediate verification of tumor presence. Fluorescein-assisted stereotactic biopsy emerges as an effective, secure alternative to conventional methods.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Fluoresceína Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosurg Rev Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Fluoresceína Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosurg Rev Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha