Your browser doesn't support javascript.
loading
Oral mucositis management with photobiomodulation, Bidens pilosa L. (Asteraceae) and Curcuma longa L. (Zingiberaceae), the FITOPROT herbal medicine, and its influence on inflammatory cytokine levels: a randomized clinical trial.
Pereira, Carlos Henrique; Martins, Allisson Filipe Lopes; Morais, Marília Oliveira; de Sousa-Neto, Sebastião Silvério; da Silva, Artur Christian Garcia; Arantes, Diego Antonio Costa; De Oliveira Moreira, Victor Hugo Lopes; Valadares, Marize Campos; Freitas, Nilceana Maya Aires; Leles, Cláudio Rodrigues; Mendonça, Elismauro Francisco.
Afiliação
  • Pereira CH; Araujo Jorge Cancer Hospital, R. 239, 206 - Setor Universitário, Goiânia, Goiás, CEP 74175-120, Brazil.
  • Martins AFL; Department of Oral Diagnosis, School of Dentistry, Universidade Evangélica de Goiás, Dentistry School, Anápolis, Goiás, CEP 75083-515, Brazil.
  • Morais MO; Araujo Jorge Cancer Hospital, R. 239, 206 - Setor Universitário, Goiânia, Goiás, CEP 74175-120, Brazil.
  • de Sousa-Neto SS; Laboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605-220, Brazil.
  • da Silva ACG; Laboratory of Education and Research in In Vitro Toxicology, Tox In, Faculty of Pharmacy, Universidade Federal de Goiás, Rodovia R2, N. 3.061, Campus Samambaia, Goiânia, Goiás, CEP 74605.170, Brazil.
  • Arantes DAC; Laboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605-220, Brazil.
  • De Oliveira Moreira VHL; Laboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605-220, Brazil.
  • Valadares MC; Laboratory of Education and Research in In Vitro Toxicology, Tox In, Faculty of Pharmacy, Universidade Federal de Goiás, Rodovia R2, N. 3.061, Campus Samambaia, Goiânia, Goiás, CEP 74605.170, Brazil.
  • Freitas NMA; Department of Radiotherapy, Araujo Jorge Cancer Hospital, R. 239, 206-Setor Universitário, Goiânia, Goiás, CEP 74175-120, Brazil.
  • Leles CR; Department of Prevention and Oral Rehabilitation, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605-220, Brazil.
  • Mendonça EF; Laboratory of Oral Pathology, School of Dentistry, Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP 74605-220, Brazil. elismaur@ufg.br.
Support Care Cancer ; 32(9): 628, 2024 Sep 02.
Article em En | MEDLINE | ID: mdl-39223301
ABSTRACT

PURPOSE:

This randomized clinical trial aimed to compare the effects of a mucoadhesive formula, containing curcuminoids from Curcuma longa L. and glycerinated extract of Bidens pilosa L. (FITOPROT), associated with photobiomodulation (PBM), and of PBM exclusively, on the incidence of oral mucositis (OM)-induced by radiotherapy (RT) in the head and neck region, and the salivary expression of inflammatory cytokines, in patients with head neck cancer.

METHODS:

Patients were randomly assigned into two intervention groups-FITOPROT + PBM (n = 25) or PBM (n = 27). PBM protocol comprised a wavelength of 660 nm, 25 mW, 0.25 J/point, and daily irradiation from the first until the last day of RT. FITOPROT was gargled twice a day. All patients underwent a preventive oral care program throughout the study. OM degree, salivary concentration of nitrite, and inflammatory (IL-1, TNFα, IL-6, IL-8, and IL-12p70), and anti-inflammatory (IL-10) cytokines were assessed at baseline, and at the 7th, 14th, 21st, and 30th RT sessions.

RESULTS:

There were no differences in the OM degree between groups, but the RT dose significantly affected the OM. The RT significantly affected the salivary nitrite, TNFα, IL-1ß, and IL-10 concentrations.

CONCLUSION:

FITOPROT associated with PBM showed limited effects on preventing the incidence of severe OM compared to PBM alone. However, FITOPROT + PBM may be associated with nitrite and cytokine balance, which may contribute to the occurrence of fewer cases of severe OM. TRIAL REGISTRATION Brazilian Clinical Trials database (ReBEC; RBR-9vddmr), registered UTN code U1111-1193-2066, registered in August 8th, 2017.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estomatite / Extratos Vegetais / Citocinas / Curcuma / Bidens / Neoplasias de Cabeça e Pescoço Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Assunto da revista: NEOPLASIAS / SERVICOS DE SAUDE Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estomatite / Extratos Vegetais / Citocinas / Curcuma / Bidens / Neoplasias de Cabeça e Pescoço Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Assunto da revista: NEOPLASIAS / SERVICOS DE SAUDE Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha