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Viral Hepatitis in Pregnant Mexican Women: Its Impact in Mother-Child Binomial Health and the Strategies for Its Eradication.
García-Romero, Carmen Selene; Guzmán, Carolina; Martínez-Ibarra, Alejandra; Cervantes, Alicia; Cerbón, Marco.
Afiliação
  • García-Romero CS; Departamento de Infectología e Inmunología, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Guzmán C; Laboratorio de Hígado, Páncreas y Motilidad, Unidad de Medicina Experimental, Hospital General de México Dr. Eduardo Liceaga, Mexico City 06720, Mexico.
  • Martínez-Ibarra A; Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04960, Mexico.
  • Cervantes A; Servicio de Genética, Hospital General de México Dr. Eduardo Liceaga, Mexico City 06720, Mexico.
  • Cerbón M; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04960, Mexico.
Pathogens ; 13(8)2024 Aug 02.
Article em En | MEDLINE | ID: mdl-39204251
ABSTRACT
Viral hepatitis is the main cause of infectious liver disease. During pregnancy, a risk of vertical transmission exists both during gestation and at birth. HAV, HBV, and HCV might progress similarly in pregnant and non-pregnant women. In this study, we found a prevalence of 0.22% of viral hepatitis in pregnant women, with a light preponderance of HCV over HAV and HBV. Here, it was observed that acute HAV infection is more symptomatic and has higher risks for the mother and fetus, in a similar manner to what has been reported for HEV. Histopathological alterations were observed in all except one placenta, indicating that it is an important tissue barrier. Regarding the Mexican strategies for viral hepatitis eradication, success may be related to vaccination at birth, whereas for HCV, the national program for eradication is aimed at treating the infection via direct-acting antiviral agents. The HBV strategy has positively impacted pregnant women and their children, diminishing the risk of vertical transmission. The HCV strategy is still in its early years, and it is expected to be just as successful. For acute hepatitis, HAV and HEV, programs promoting hand washing and those aimed at providing clean food and water are applicable as preventive strategies, alongside other programs such as vaccination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Pathogens Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Pathogens Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça