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Gut Microbiome Is Related to Cognitive Impairment in Peritoneal Dialysis Patients.
Martín-Del-Campo, Fabiola; Vega-Magaña, Natali; Salazar-Félix, Noé A; Cueto-Manzano, Alfonso M; Peña-Rodríguez, Marcela; Cortés-Sanabria, Laura; Romo-Flores, María L; Rojas-Campos, Enrique.
Afiliação
  • Martín-Del-Campo F; Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico.
  • Vega-Magaña N; Laboratory of Pathology, Department of Microbiology and Pathology, Health Sciences University Center, University of Guadalajara, Sierra Mojada #950, Guadalajara 44350, Mexico.
  • Salazar-Félix NA; Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico.
  • Cueto-Manzano AM; Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico.
  • Peña-Rodríguez M; Research Institute on Chronic and Degenerative Diseases, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada #950, Guadalajara 44350, Mexico.
  • Cortés-Sanabria L; Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico.
  • Romo-Flores ML; Department of Nephrology, Regional General Hospital 46, Mexican Institute of Social Security, Lázaro Cárdenas Av. 1060, Guadalajara 44910, Mexico.
  • Rojas-Campos E; Biomedical Research Unit 02, Specialties Hospital, Western National Medical Center, Mexican Institute of Social Security, Belisario Dominguez #1000, Guadalajara 44320, Mexico.
Nutrients ; 16(16)2024 Aug 12.
Article em En | MEDLINE | ID: mdl-39203796
ABSTRACT
Gut microbiota disturbances may influence cognitive function, increasing uremic toxins and inflammation in dialysis patients; therefore, we aimed to evaluate the association of the gut microbiota profile with cognitive impairment (CI) in patients on automated peritoneal dialysis (APD). In a cross-sectional study, cognitive function was evaluated using the Montreal Cognitive Assessment in 39 APD patients and classified as normal cognitive function and CI. The gut microbiota was analyzed using the 16S rRNA gene sequencing approach. All patients had clinical, biochemical and urea clearance evaluations. Eighty-two percent of patients were men, with a mean age of 47 ± 24 years and 11 (7-48) months on PD therapy; 64% had mild CI. Patients with CI were older (53 ± 16 vs. 38 ± 14, p = 0.006) and had a higher frequency of diabetes mellitus (56% vs. 21%, p = 0.04) and constipation (7% vs. 48%, p = 0.04) and lower creatinine concentrations (11.3 ± 3.7 vs. 14.9 ± 5.4, p = 0.02) compared to normal cognitive function patients. Patients with CI showed a preponderance of S24_7, Rikenellaceae, Odoribacteraceae, Odoribacter and Anaerotruncus, while patients without CI had a greater abundance of Dorea, Ruminococcus, Sutterella and Fusobacteria (LDA score (Log10) > 2.5; p < 0.05). After glucose and age adjustment, Odoribacter was still associated with CI. In conclusion, patients with CI had a different gut microbiota characterized by the higher abundance of indole-producing and mucin-fermenting bacteria compared to normal cognitive function patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diálise Peritoneal / Disfunção Cognitiva / Microbioma Gastrointestinal Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diálise Peritoneal / Disfunção Cognitiva / Microbioma Gastrointestinal Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça