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The Frequency of Risk Factors for Cleft Lip and Palate in Mexico: A Systematic Review.
López-Verdín, Sandra; Solorzano-López, Judith A; Bologna-Molina, Ronell; Molina-Frechero, Nelly; Tremillo-Maldonado, Omar; Toral-Rizo, Victor H; González-González, Rogelio.
Afiliação
  • López-Verdín S; Health Science Center, Research Institute of Dentistry, Universidad de Guadalajara, Guadalajara 44100, Mexico.
  • Solorzano-López JA; Health Science Center, Research Institute of Dentistry, Universidad de Guadalajara, Guadalajara 44100, Mexico.
  • Bologna-Molina R; Molecular Pathology Area, School of Dentistry, Universidad de la República, Montevideo 11400, Uruguay.
  • Molina-Frechero N; Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango, Durango 34070, Mexico.
  • Tremillo-Maldonado O; Department of Health Care, Universidad Autónoma Metropolitana Xochimilco, México City 04960, Mexico.
  • Toral-Rizo VH; Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango, Durango 34070, Mexico.
  • González-González R; School of Dentistry, National Autonomous University of Mexico, Toluca de Lerdo 50000, Mexico.
Diagnostics (Basel) ; 14(16)2024 Aug 12.
Article em En | MEDLINE | ID: mdl-39202241
ABSTRACT

BACKGROUND:

Cleft lip and palate is an anomaly that affects both women and men. It is considered to be among the most frequent congenital abnormalities and is related to modifications in chromosomal DNA and multiple genetic alterations. This anomaly can also be associated with various environmental factors, such as tobacco and alcohol consumption, medication use, and exposure to different environmental and industrial toxic substances. The objective of this study was to document the frequency of risk factors related to cleft lip and palate through a systematic review of Mexican studies.

METHODS:

In this systematic review, a bibliographic search was conducted following PRISMA guidelines in the databases Scielo, ScienceDirect, PubMed, and EBSCO. Keywords related to cleft lip and palate, epidemiology, and risk factors were used. In all, 3 independent reviewers (J.A.S.L., S.L.V., and N.M.F.) selected and evaluated a total of 17 articles included in this analysis, achieving a coefficient of κ = 0.84.

RESULTS:

The analysis revealed that the highest frequency of conducted studies was in the State of Mexico. The most common risk factors identified were environmental, pharmacological, consumption habits, and gynecological factors.

CONCLUSIONS:

Identifying the main risk factors for cleft lip and palate in the Mexican population will enable the implementation of preventive measures aimed at reducing exposure to these factors. Additionally, early intervention can improve the quality of life for individuals affected by this condition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: Mexico Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: México País de publicação: Suíça