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Impact of cardiac structure and function on exercise intolerance in Chagas cardiomyopathy: Insights from CPET and echocardiography.
Pereira, Jhessica Macieira; Magnani, Enrico de Francisco; Tanaka, Denise Mayumi; Damasceno, Thayrine Rosa; Oliveira, Rafael Dias de Brito; Carvalho, Eduardo Elias Vieira de; Pereira, Danielle Aparecida Gomes; Costa, Henrique Silveira; Gadioli, Leonardo Pippa; Azevedo, Eduardo Rubio; Crescêncio, Júlio César; Gallo Júnior, Lourenço; Simões, Marcus Vinicius; de Oliveira, Luciano Fonseca Lemos.
Afiliação
  • Pereira JM; Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Magnani EF; Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Tanaka DM; Medical School of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
  • Damasceno TR; Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Oliveira RDB; Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Carvalho EEV; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil.
  • Pereira DAG; Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Costa HS; Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
  • Gadioli LP; Medical School of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
  • Azevedo ER; Medical School of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
  • Crescêncio JC; Medical School of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
  • Gallo Júnior L; Medical School of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
  • Simões MV; Medical School of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
  • de Oliveira LFL; Federal University of Minas Gerais, Belo Horizonte, Brazil; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil. Electronic address: oliveiralfl@hotmail.com.
Int J Cardiol ; 416: 132488, 2024 Dec 01.
Article em En | MEDLINE | ID: mdl-39191292
ABSTRACT

INTRODUCTION:

Chronic Chagas cardiomyopathy (CCC), the most severe clinical condition of Chagas disease, often leads to a reduction in functional capacity and the appearance of symptoms such as fatigue and dyspnea on exertion. However, its determinant factors remain unclear. We aimed to evaluate the peak oxygen consumption (VO2peak) in patients with CCC and identify its determining factors.

METHODS:

An observational study with 97 CCC patients was conducted. Patients underwent clinical examination, cardiopulmonary exercise test (CPET), and echocardiography as part of the standard clinical evaluation. Multivariate linear regression was used to identify independent clinical and echocardiographic predictors of VO2peak and percentage of predicted VO2.

RESULTS:

Mean age of study patients was 55.9 ± 13.4 years, median left ventricle ejection fraction (LVEF) was 40 (26-61.5) % and median VO2peak was 16.1 (12.1-20.8) ml/Kg/min. 36 patients presented preserved LVEF and 61 presented reduced LVEF. There were significant differences in almost all CPET variables (p < 0.05) between these two groups. VO2peak was associated with age, male sex, NYHA functional class, LVEF, left atrium diameter, LV diastolic diameter, E wave, LV mass index, and pulmonary artery systolic pressure (PASP). Age, male sex, LVEF, and E wave remained independently associated with VO2peak in the multivariate analysis (R2 = 0.69), furthermore, only LVEF and E wave were associated with the predicted VO2 percentage (R2 = 0.53).

CONCLUSION:

In patients with CCC, disease severity, male sex, LV systolic and diastolic function influence the functional capacity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ecocardiografia / Cardiomiopatia Chagásica / Tolerância ao Exercício / Teste de Esforço Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cardiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ecocardiografia / Cardiomiopatia Chagásica / Tolerância ao Exercício / Teste de Esforço Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cardiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda