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Aloe-emodin relieves allergic contact dermatitis pruritus by inhibiting mast cell degranulation.
Yang, Yan; Sun, Jianmei; You, Huan; Sun, Yuling; Song, Yizhi; Shen, Zhouyang; Liu, Tongtong; Guan, Donglang; Zhou, Yuan; Cheng, Shuo; Wang, Changming; Yu, Guang; Zhu, Chan; Tang, Zongxiang.
Afiliação
  • Yang Y; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Sun J; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • You H; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Sun Y; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China; Department of Pharmacy, General Hospital of Eastern Theater Command, Nanjing, 210002, China.
  • Song Y; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Shen Z; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Liu T; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Guan D; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Zhou Y; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Cheng S; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Wang C; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Yu G; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China.
  • Zhu C; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China. Electronic address: zhuchan@njucm.edu.cn.
  • Tang Z; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, JS, China. Electronic address: tangzxlab@njucm.edu.cn.
Immunol Lett ; 270: 106902, 2024 Aug 22.
Article em En | MEDLINE | ID: mdl-39181335
ABSTRACT
Urushiol-induced allergic contact dermatitis (ACD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to pruritus and eczematous lesions. ACD is triggered by immune imbalance. Aloe emodin is an anthraquinone derivative extracted from rhubarb, aloe and other traditional Chinese medicines. It has a wide range of pharmacological effects, including anti-inflammatory, anti-tumor, and anti-allergic effects. The purpose of our study was to demonstrate the effectiveness of aloe-emodin on urushiol-induced acute pruritus and allergic contact dermatitis. The results showed that urushiol could stimulate keratinocytes to release chemokines CXCL1, CXCL2, CCL2, TSLP, and TNF-α, which recruit or activate mast cells. Aloe-emodin treatment inhibited inflammatory-response-induced mast cell degranulation in skin lesions and suppressed the expression of inflammatory cytokines, such as interleukin-4, and interleukin-6. Therefore, the results indicate that aloe-emodin can improve urushiol-induced acute pruritus and allergic contact dermatitis in mice by inhibiting mast cell degranulation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Immunol Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Immunol Lett Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Holanda