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Mid-pregnancy circulating cytokine levels, placental efficiency and their relationship with preterm birth.
Grandi, Carlos; Salomão, Karina Bezerra; de Freitas, Stella Felippe; Rocha, Paulo Ricardo Higassiaraguti; Cavalli, Ricardo de Carvalho; Cardoso, Viviane Cunha.
Afiliação
  • Grandi C; Argentine Society of Pediatrics Buenos Aires Argentina Argentine Society of Pediatrics, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
  • Salomão KB; Faculty of Medicine of Ribeirão Preto Universidade de São Paulo Ribeirão PretoSP Brazil Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • de Freitas SF; Faculty of Medicine of Ribeirão Preto Universidade de São Paulo Ribeirão PretoSP Brazil Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • Rocha PRH; Faculty of Medicine of Ribeirão Preto Universidade de São Paulo Ribeirão PretoSP Brazil Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • Cavalli RC; Faculty of Medicine of Ribeirão Preto Universidade de São Paulo Ribeirão PretoSP Brazil Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • Cardoso VC; Faculty of Medicine of Ribeirão Preto Universidade de São Paulo Ribeirão PretoSP Brazil Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Rev Bras Ginecol Obstet ; 462024.
Article em En | MEDLINE | ID: mdl-39176195
ABSTRACT

Objective:

To assess a panel of cytokines and placental insufficiency with the risk of preterm delivery (PTD).

Methods:

Nested case-control study into the BRISA birth cohort. Eighty-two mother-infant-placenta pairs were selected at 20+0 to 25+6 weeks. Circulating biomarker levels were performed using Luminex flowmetric xMAP technology. Cytokines classified as Th1, Th2 or Th17 and other biomarkers were selected. The ratio between birth weight and placental weight (BW/PW) was used as a proxy for placental efficiency. Spearman correlation, univariate analyses and logistic regression models were calculated. Sensitivity, specificity, positive and negative likelihood ratios were calculated using the Receiver Operating Characteristic curve.

Results:

Mean gestational age was 250 days, 14,6% were small for gestational age, 4,8% large for gestational age and 13,4% stunted. Placental efficiency was higher for term newborns (p<0,001), and 18/22 (81%) preterm biomarker values were higher than the control group. Th1 cytokines were highly correlated, while the weakest correlation was observed in other biomarkers. Less education was associated with a higher risk of PTD (p = 0.046), while there was no appreciable difference in the risk of PTD for placental insufficiency. Biomarkers showed negligible adjusted OR of PTD (0.90 to 1.02). IL-6, IL-8, IL-1ß, TNFß, IL-4, IL-13, GCSF, MIP1A, VEGF, EGF, and FGF2 presented a higher sensitivity ranging from 75.56% to 91.11%.

Conclusion:

IL-8, IL-12p40, IL-4, IL-13, GCSF, MIP1B, and GMSF in asymptomatic pregnant women were associated with PTD. This finding suggests an activation of maternal inflammatory response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Placenta / Citocinas / Nascimento Prematuro Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Rev Bras Ginecol Obstet Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Placenta / Citocinas / Nascimento Prematuro Limite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Rev Bras Ginecol Obstet Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Argentina País de publicação: Brasil