Your browser doesn't support javascript.
loading
1H, 15N, and 13C resonance assignments of the N-terminal domain and ser-arg-rich intrinsically disordered region of the nucleocapsid protein of the SARS-CoV-2.
Bezerra, Peter R; Vasconcelos, Ariana A; Almeida, Vitor S; Neves-Martins, Thais C; Mebus-Antunes, Nathane C; Almeida, Fabio C L.
Afiliação
  • Bezerra PR; National Center of Nuclear Magnetic Resonance, Institute of Medical Biochemistry (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Vasconcelos AA; National Center of Nuclear Magnetic Resonance (CNRMN), National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Almeida VS; National Center of Nuclear Magnetic Resonance, Institute of Medical Biochemistry (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Neves-Martins TC; National Center of Nuclear Magnetic Resonance (CNRMN), National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Mebus-Antunes NC; National Center of Nuclear Magnetic Resonance, Institute of Medical Biochemistry (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Almeida FCL; National Center of Nuclear Magnetic Resonance (CNRMN), National Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Biomol NMR Assign ; 18(2): 219-225, 2024 Dec.
Article em En | MEDLINE | ID: mdl-39174826
ABSTRACT
The nucleocapsid (N) protein of SARS-CoV-2 is a multifunctional protein involved in nucleocapsid assembly and various regulatory functions. It is the most abundant protein during viral infection. Its functionality is closely related to its structure, which comprises two globular domains, the N-terminal domain (NTD) and the C-terminal domain (CTD), flanked by intrinsically disordered regions. The linker between the NTD and CTD includes a Serine-Arginine rich (SR) region, which is crucial for the regulation of the N protein's function. Here, we report the near-complete assignment of the construct containing the NTD followed by the SR region (NTD-SR). Additionally, we describe the dynamic nature of the SR region and compare it with all other available chemical shift assignments reported for the SR region.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Ressonância Magnética Nuclear Biomolecular / Proteínas Intrinsicamente Desordenadas / Domínios Proteicos / Proteínas do Nucleocapsídeo de Coronavírus / SARS-CoV-2 / Isótopos de Nitrogênio Idioma: En Revista: Biomol NMR Assign Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA NUCLEAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Ressonância Magnética Nuclear Biomolecular / Proteínas Intrinsicamente Desordenadas / Domínios Proteicos / Proteínas do Nucleocapsídeo de Coronavírus / SARS-CoV-2 / Isótopos de Nitrogênio Idioma: En Revista: Biomol NMR Assign Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA NUCLEAR Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda