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Exploring extracellular vesicles in zoonotic helminth biology: implications for diagnosis, therapeutic and delivery.
Qadeer, Abdul; Wajid, Abdul; Rafey, Hafiz Abdul; Nawaz, Saqib; Khan, Sawar; Rahman, Sajid Ur; Alzahrani, Khalid J; Khan, Muhammad Zahoor; Alsabi, Mohammad Nafi Solaiman; Ullah, Hanif; Safi, Sher Zaman; Xia, Zanxian; Zahoor, Muhammad.
Afiliação
  • Qadeer A; Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China.
  • Wajid A; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Rafey HA; Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
  • Nawaz S; Shifa College of Pharmaceutical Sciences, Faculty of Pharmaceutical and Allied Health Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
  • Khan S; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Rahman SU; Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China.
  • Alzahrani KJ; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Khan MZ; Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.
  • Alsabi MNS; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
  • Ullah H; Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
  • Safi SZ; Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
  • Xia Z; College of Agricultural Science and Engineering, Liaocheng University, Liaocheng, Shandong, China.
  • Zahoor M; Department of Basic Veterinary Medical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Front Cell Infect Microbiol ; 14: 1424838, 2024.
Article em En | MEDLINE | ID: mdl-39165921
ABSTRACT
Extracellular vesicles (EVs) have emerged as key intercellular communication and pathogenesis mediators. Parasitic organisms' helminths, cause widespread infections with significant health impacts worldwide. Recent research has shed light on the role of EVs in the lifecycle, immune evasion, and disease progression of these parasitic organisms. These tiny membrane-bound organelles including microvesicles and exosomes, facilitate the transfer of proteins, lipids, mRNAs, and microRNAs between cells. EVs have been isolated from various bodily fluids, offering a potential diagnostic and therapeutic avenue for combating infectious agents. According to recent research, EVs from helminths hold great promise in the diagnosis of parasitic infections due to their specificity, early detection capabilities, accessibility, and the potential for staging and monitoring infections, promote intercellular communication, and are a viable therapeutic tool for the treatment of infectious agents. Exploring host-parasite interactions has identified promising new targets for diagnostic, therapy, and vaccine development against helminths. This literature review delves into EVS's origin, nature, biogenesis, and composition in these parasitic organisms. It also highlights the proteins and miRNAs involved in EV release, providing a comprehensive summary of the latest findings on the significance of EVs in the biology of helminths, promising targets for therapeutic and diagnostic biomarkers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Helmintíase / Helmintos / Interações Hospedeiro-Parasita Limite: Animals / Humans Idioma: En Revista: Front Cell Infect Microbiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Helmintíase / Helmintos / Interações Hospedeiro-Parasita Limite: Animals / Humans Idioma: En Revista: Front Cell Infect Microbiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China País de publicação: Suíça