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Brazilian pediatric patients with gliomas: treatment characteristics and survival outcomes.
Starling, Maria Thereza Mansur; Pereira, Allan Andresson Lima; Arruda, Gustavo Viani; Paiva, Wellingson Silva; Neville, Iuri Santana; Restin, Felipe Cicci Farinha; Gouveia, André Guimarães; de Sousa, Cecília Félix Penido Mendes; Maldaun, Marcos Vinícius Calfat; Pahl, Felix Hendrik; Hanna, Samir Abdallah; de Moraes, Fabio Ynoe; Marta, Gustavo Nader.
Afiliação
  • Starling MTM; Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
  • Pereira AAL; Department of Clinical Oncology, Hospital Sírio-Libanês, Brasilia, Brazil.
  • Arruda GV; Ribeirão Preto Medical School, Department of Medical Imaging, Hematology and Oncology of University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
  • Paiva WS; Latin America Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.
  • Neville IS; Division of Neurosurgery Department of Neurology Faculdade de Medicina da Universidade de São Paulo São Paulo, Brazil.
  • Restin FCF; Division of Neurosurgery Department of Neurology Faculdade de Medicina da Universidade de São Paulo São Paulo, Brazil.
  • Gouveia AG; Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • de Sousa CFPM; Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
  • Maldaun MVC; Juravinski Cancer Centre, Department of Oncology, Division of Radiation Oncology, Hamilton, ON, Canada.
  • Pahl FH; Latin America Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.
  • Hanna SA; Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil.
  • de Moraes FY; Neurosurgery Group, Hospital Sírio-Libanês, Brazil.
  • Marta GN; Neurosurgery Group, Hospital Sírio-Libanês, Brazil.
Rep Pract Oncol Radiother ; 29(1): 90-96, 2024.
Article em En | MEDLINE | ID: mdl-39165603
ABSTRACT

Background:

The current study aimed to determine the overall survival (OS) rates of patients diagnosed with pediatric gliomas in Brazil, accounting for the influence of age, treatment modalities, and tumor site, using a population-based national database. Materials and

methods:

Patients diagnosed with pediatric gliomas of central nervous system (CNS) from 1999-2020 were identified from The Fundação Oncocentro de São Paulo public database. The Kaplan-Meier and the log-rank test were used for survival analysis.

Results:

A total of 1296 patients were included. The most common histologic tumor types were glioblastomas (38.27%; n = 496), pilocytic astrocytoma (32.87%; n = 426), and astrocytoma grade II (20.76%; n = 269). A total of 379 (29.24%) had brainstem tumors. The mean follow-up was 135 months [95% confidence interval (CI) 128-142\. The 1-year, 3-year 5-year OS for pilocytic astrocytoma were 93.72%, 89.98%, and 88.97%; for grade II gliomas, 80.36%, 71.89%, and 68.60%; for grade III gliomas, 53.72%; 31.87%, and 28.33%; and for glioblastoma, 52.90%, 28.76%, 25.20%, respectively. Brainstem tumors had the worse OS compared to no brainstem tumors (p = 0.001). For high-grade glioma (grade III/IV), excluding brainstem tumors (n = 570), young patients had greater median OS (0 to 3 years22 months; 4 to 18 years13 months; p = 0.005). Regarding the treatment modalities, combined treatments were associated with higher median survival compared to less intensive therapy (surgery 11 months; surgery and chemotherapy 16 months; surgery, radiotherapy, and chemotherapy 20 months; p = 0.005).

Conclusion:

In our cohort, low-grade gliomas had favorable prognoses and outcomes. Patients diagnosed with glioblastomas and brainstem gliomas had the worst OS. For high-grade gliomas, undergoing treatment de-intensification in the Brazilian pediatric population is associated with worse survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rep Pract Oncol Radiother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Polônia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rep Pract Oncol Radiother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Polônia